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protein coding gene - rlp7 (SPAC664.06) - ribosomal L7-like protein involved in ribosome biogenesis

Gene summary

Standard name
rlp7
Systematic ID
SPAC664.06
Product
ribosomal L7-like protein involved in ribosome biogenesis
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rpl7, rpl7-3, rpl703
UniProt ID
P17937
ORFeome ID
13/13G06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1712785..1713921 forward strand

Annotation

GO biological process

GO:1902626 - assembly of large subunit precursor of preribosome

References:

GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

References:

GO cellular component

GO:0022625 - cytosolic large ribosomal subunit

References:

GO:0005730 - nucleolus

References:

GO:0030684 - preribosome

References:

GO:0030687 - preribosome, large subunit precursor

References:

GO molecular function

GO:0003723 - RNA binding

References:

GO:0003735 - structural constituent of ribosome

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0001137 - ncRNA in intron

Protein features

IDNameInterPro nameDB name
PF08079Ribosomal_L30_NRibosomal_uL30_N_eukPFAM
PF00327Ribosomal_L30Ribosomal_uL30_ferredoxin-likePFAM
cd01657Ribosomal_L7_archeal_eukRibosomal_uL30_euk_arcCDD
PS00634RIBOSOMAL_L30Ribosomal_uL30_CSPROSITE_PATTERNS
G3DSA:3.30.1390.20:FF:000003FUNFAM
G3DSA:1.10.15.30:FF:000001FUNFAM
SSF55129Ribosomal protein L30p/L7eRibo_uL30_ferredoxin-like_sfSUPERFAMILY
G3DSA:3.30.1390.20Ribo_uL30_ferredoxin-like_sfGENE3D
PTHR1152460S RIBOSOMAL PROTEIN L7Ribosomal_uL30PANTHER
CoilCoilCOILS
TIGR01310uL30_eukRibosomal_uL30_eukNCBIFAM

Orthologs

References / Literature

PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.
Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:2388837 - Isolation of a Schizosaccharomyces pombe homologue to the rat ribosomal protein, L7.
Murray JM et al. Nucleic Acids Res 1990 Aug 11;18(15):4590
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:32168916 - Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA.
Bergot T et al. Cancers (Basel) 2020 Mar 11;12(3)
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:36423630 - Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Ugolini I et al. Mol Cell 2022 Dec 01;82(23):4443-4457.e9
PMID:37913773 - TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation.
Hirai H et al. Cell Rep 2023 Nov 28;42(11):113320
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:9001235 - Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradation.
Nam K et al. Mol Cell Biol 1997 Feb;17(2):809-18
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399