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protein coding gene - ggt1 (SPAC664.09) - glutathione gamma-glutamate hydrolase Ggt1

Gene summary

Standard name
ggt1
Systematic ID
SPAC664.09
Product
glutathione gamma-glutamate hydrolase Ggt1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9US04
ORFeome ID
26/26E05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1719109..1721701 forward strand

Annotation

Disease association

MONDO:0009285 - gamma-glutamyl transpeptidase deficiency

References:

GO biological process

GO:1990748 - cellular detoxification

References:

GO:0006751 - glutathione catabolic process

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GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0000324 - fungal-type vacuole

References:

GO:0005886 - plasma membrane

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GO molecular function

GO:0036374 - glutathione gamma-glutamate hydrolase

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Modification

MOD:00006 - N-glycosylated residue

References:

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001283 - decreased protein level during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0001521 - increased cellular glutathione level during vegetative growth

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Genotypes:

FYPO:0006090 - increased glutathione hydrolase activity

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0004135 - resistance to copper

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0001516 - resistance to mercury

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01019G_glu_transpeptPfam
PR01210GGTRANSPTASEPRINTS
G3DSA:1.10.246.130:FF:000005CATH-FunFam
G3DSA:3.60.20.40:FF:000001CATH-FunFam
G3DSA:1.10.246.130GGT_lsubCATH-Gene3D
G3DSA:3.60.20.40GGT_ssub_CCATH-Gene3D
SSF56235Ntn_hydrolases_NSUPERFAMILY
PTHR11686GGT_peptidasePANTHER
TIGR00066g_glut_transGGT_peptidaseNCBIFAM
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:15052323 - Characterization and regulation of the gamma-glutamyl transpeptidase gene from the fission yeast Schizosaccharomyces pombe.
Park HJ et al. Can J Microbiol 2004 Jan;50(1):61-6
PMID:15765057 - The Schizosaccharomyces pombe gene encoding gamma-glutamyl transpeptidase I is regulated by non-fermentable carbon sources and nitrogen starvation.
Kim HG et al. J Microbiol 2005 Feb;43(1):44-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:18337696 - Nitrogen depletion causes up-regulation of glutathione content and gamma-glutamyltranspeptidase in Schizosaccharomyces pombe.
Song SH et al. J Microbiol 2008 Feb;46(1):70-4
GO_REF:0000051 - S. pombe keyword mapping
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643