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protein coding gene - srb8 (SPAC688.08) - mediator complex subunit Med12

Gene summary

Standard name
srb8
Systematic ID
SPAC688.08
Product
mediator complex subunit Med12
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
med12
UniProt ID
Q9P6L8
ORFeome ID
48/48F01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3123163..3126653 forward strand

Annotation

Disease association

MONDO:0010477 - blepharophimosis - intellectual disability syndrome, MKB type

References:

MONDO:0012997 - cholestasis-pigmentary retinopathy-cleft palate syndrome

References:

MONDO:0010590 - FG syndrome 1

References:

MONDO:0030030 - Nizon-Isidor syndrome

References:

MONDO:0010655 - X-linked intellectual disability with marfanoid habitus

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GO biological process

GO:0022408 - negative regulation of cell-cell adhesion

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO cellular component

GO:0016592 - mediator complex

References:

GO molecular function

GO:0003713 - transcription coactivator activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000155 - increased flocculation

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000108 - frameshifted

References:

PBO:0091456 - I:g.3125118_3125119insT

References:

PBO:0000129 - sequence error in genomic data

References:

Protein features

IDNameInterPro nameDB name
PF09497Med12Mediator_Med12PFAM
SM01281Med12_2Mediator_Med12SMART
PTHR46567MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12PANTHER

Orthologs

References / Literature

PMID:26615217 - Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.
Hu W et al. Genome Biol Evol 2015 Nov 27;7(12):3496-510
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:18310102 - Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.
Linder T et al. Nucleic Acids Res 2008 May;36(8):2489-504
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25154415 - Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.
Banyai G et al. Mol Cell Biol 2014 Nov;34(21):4008-18
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:28515143 - Cyclin C influences the timing of mitosis in fission yeast.
Banyai G et al. Mol Biol Cell 2017 Jul 01;28(13):1738-1744
PMID:20622008 - A chromatin-remodeling protein is a component of fission yeast mediator.
Khorosjutina O et al. J Biol Chem 2010 Sep 24;285(39):29729-37
PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8
PMID:12738880 - TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.
Samuelsen CO et al. Proc Natl Acad Sci U S A 2003 May 27;100(11):6422-7