protein coding gene - rim2 (SPAC688.09) - mitochondrial carrier, pyrimidine nucleotide Rim2

Gene summary

Standard name: rim2
Systematic ID: SPAC688.09
Product: mitochondrial carrier, pyrimidine nucleotide Rim2
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9P6L7
ORFeome ID: 17/17G11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 3127660..3129464 forward strand

Annotation

Disease association

MONDO:0859362 - hyperinsulinemic hypoglycemia, familial, 8

References:

PB_REF:0000006

GO biological process

GO:1990519 - pyrimidine nucleotide import into mitochondrion

References:

GO_REF:0000033

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO_REF:0000024

GO molecular function

GO:0015218 - pyrimidine nucleotide transmembrane transporter activity

References:

GO_REF:0000033

Protein features

PBO:0111775 - mitochondrial carrier

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

rim2delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

rim2delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

Protein features

ID	Name	InterPro name	DB name
PF00153	Mito_carr	MCP_transmembrane	Pfam
PS50920	SOLCAR	MCP_transmembrane	PROSITE profiles
PR00926	MITOCARRIER	MCP	PRINTS
G3DSA:1.50.40.10:FF:000088			CATH-FunFam
G3DSA:1.50.40.10		MCP_dom_sf	CATH-Gene3D
SSF103506		MCP_dom_sf	SUPERFAMILY
PTHR45829		SLC25A33/36-like	PANTHER

Orthologs

SLC25A36 (HGNC:25554) Homo sapiens
SLC25A33 (HGNC:29681) Homo sapiens
rim2 (SJAG_00154) Schizosaccharomyces japonicus
RIM2 (YBR192W) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.: Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees