protein coding gene - end4 (SPAC688.11) - actin filament endocytic membrane adaptor End4

Gene summary

Standard name

end4

Systematic ID

SPAC688.11

Product

actin filament endocytic membrane adaptor End4

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

sla2

UniProt ID

Q9P6L5

ORFeome ID

30/30C09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3134987..3138666 forward strand

Annotation

Protein features

Orthologs

• HIP1R (HGNC:18415) Homo sapiens
• HIP1 (HGNC:4913) Homo sapiens
• end4 (SJAG_00152) Schizosaccharomyces japonicus
• SLA2 (YNL243W) Saccharomyces cerevisiae

References / Literature

PMID:15827087 - End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe.

Castagnetti S et al. J Cell Sci 2005 May 01;118(Pt 9):1843-50

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:27974503 - Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast.

Hoya M et al. Genetics 2017 Feb;205(2):673-690

PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.

Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279

PMID:19624755 - Deletion mutants of AP-1 adaptin subunits display distinct phenotypes in fission yeast.

Ma Y et al. Genes Cells 2009 Aug;14(8):1015-28

PMID:29134248 - The ancient claudin Dni2 facilitates yeast cell fusion by compartmentalizing Dni1 into a membrane subdomain.

Curto MÁ et al. Cell Mol Life Sci 2018 May;75(9):1687-1706

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:37831774 - Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors.

Ren Y et al. Sci Adv 2023 Oct 13;9(41):eadi1535

PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.

Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:18346214 - btn1 affects endocytosis, polarization of sterol-rich membrane domains and polarized growth in Schizosaccharomyces pombe.

Codlin S et al. Traffic 2008 Jun;9(6):936-50

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:21832151 - Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.

Kashiwazaki J et al. Mol Biol Cell 2011 Oct;22(19):3658-70

GO_REF:0000002 - Comments

PMID:15975911 - The novel fission yeast protein Pal1p interacts with Hip1-related Sla2p/End4p and is involved in cellular morphogenesis.

Ge W et al. Mol Biol Cell 2005 Sep;16(9):4124-38

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:25837586 - Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.

Bendezú FO et al. PLoS Biol 2015 Apr;13(4):e1002097

PMID:22891673 - Fission yeast sec3 bridges the exocyst complex to the actin cytoskeleton.

Jourdain I et al. Traffic 2012 Nov;13(11):1481-95

PMID:25040903 - Eng2 is a component of a dynamic protein complex required for endocytic uptake in fission yeast.

Encinar del Dedo J et al. Traffic 2014 Oct;15(10):1122-42

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:23727096 - Actin filament severing by cofilin dismantles actin patches and produces mother filaments for new patches.

Chen Q et al. Curr Biol 2013 Jul 08;23(13):1154-62

PMID:20624220 - Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.

Cadou A et al. Mol Microbiol 2010 Sep;77(5):1186-202

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:20587778 - Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.

Sirotkin V et al. Mol Biol Cell 2010 Aug 15;21(16):2894-904

PMID:19808887 - Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.

Attanapola SL et al. J Cell Sci 2009 Nov 01;122(Pt 21):3856-61

PMID:26345368 - A new phosphate-starvation response in fission yeast requires the endocytic function of myosin I.

Petrini E et al. J Cell Sci 2015 Oct 15;128(20):3707-13

PMID:30049830 - Huntingtin-interacting protein 1 (HIP1) regulates arthritis severity and synovial fibroblast invasiveness by altering PDGFR and Rac1 signalling.

Laragione T et al. Ann Rheum Dis 2018 Nov;77(11):1627-1635

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:35024575 - Isolated THATCH domain of End4 is unable to bind F-actin independently in the fission yeast Schizosaccharomyces pombe .

Ren Y et al. MicroPubl Biol 2022;2022

PMID:19366728 - Genetic control of cellular quiescence in S. pombe.

Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:20838651 - A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Kouranti I et al. PLoS Biol 2010 Sep 07;8(9)

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25422470 - Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.

Scheffler K et al. Proc Natl Acad Sci U S A 2014 Dec 16;111(50):17899-904

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:39276354 - Cross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis.

Ren Y et al. Cell Rep 2024 Sep 12;43(9):114725

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Ma Y et al. PLoS One 2011;6(8):e23422

PMID:15300681 - Characterization of end4+, a gene required for endocytosis in Schizosaccharomyces pombe.

Iwaki T et al. Yeast 2004 Jul 30;21(10):867-81

PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhou X et al. PLoS One 2013;8(5):e65904

PMID:26960792 - Rga6 is a Fission Yeast Rho GAP Involved in Cdc42 Regulation of Polarized Growth.

Revilla-Guarinos MT et al. Mol Biol Cell 2016 Mar 09;27(9):1524-35

PMID:27852900 - Gradients of phosphatidylserine contribute to plasma membrane charge localization and cell polarity in fission yeast.

Haupt A et al. Mol Biol Cell 2017 Jan 01;28(1):210-220

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:39156640 - Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic.

Ramos M et al. iScience 2024 Aug 16;27(8):110477

PMID:26749213 - The AP-2 complex is required for proper temporal and spatial dynamics of endocytic patches in fission yeast.

de León N et al. Mol Microbiol 2016 May;100(3):409-24

PMID:34666001 - Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast.

Neeli-Venkata R et al. Dev Cell 2021 Oct 25;56(20):2856-2870.e7

PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.

Bitton DA et al. Genetics 2011 Apr;187(4):1207-17

PMID:22252817 - A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Fang Y et al. Antimicrob Agents Chemother 2012 Apr;56(4):1949-59