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protein coding gene - rpp40 (SPAC6C3.09) - RNase P and RNase MRP subunit Rpp40

Gene summary

Standard name
rpp40
Systematic ID
SPAC6C3.09
Product
RNase P and RNase MRP subunit Rpp40
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10312
ORFeome ID
20/20B04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2339797..2341304 forward strand

Annotation

GO biological process

GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

References:

GO:0001682 - tRNA 5'-leader removal

References:

GO:0008033 - tRNA processing

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005655 - nucleolar ribonuclease P complex

References:

GO:0005634 - nucleus

References:

GO:0000172 - ribonuclease MRP complex

References:

GO molecular function

GO:0000171 - ribonuclease MRP activity

References:

GO:0004526 - ribonuclease P activity

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF08584Ribonuc_P_40RNase_P_Rpp40PFAM
PTHR15396RIBONUCLEASE P PROTEIN SUBUNIT P40RNase_P_Rpp40PANTHER

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:6262315 - Partial purification of RNase P from Schizosaccharomyces pombe.
Kline L et al. J Biol Chem 1981 May 25;256(10):5058-63
PMID:25401760 - RNase MRP cleaves pre-tRNASer-Met in the tRNA maturation pathway.
Saito Y et al. PLoS One 2014;9(11):e112488