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protein coding gene - tom20 (SPAC6F12.07) - mitochondrial TOM complex subunit Tom20

Gene summary

Standard name
tom20
Systematic ID
SPAC6F12.07
Product
mitochondrial TOM complex subunit Tom20
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14225
ORFeome ID
11/11F06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1321279..1322357 forward strand

Annotation

GO biological process

GO:7770063 - beta barrel protein insertion into mitochondrial outer membrane

References:

GO:0045041 - protein import into mitochondrial intermembrane space

References:

GO:0030150 - protein import into mitochondrial matrix

References:

GO:7770060 - TOM-TIM23-SORT-mediated protein insertion into the mitochondrial inner membrane

References:

GO:0016031 - tRNA import into mitochondrion

References:

GO cellular component

GO:0005739 - mitochondrion

References:

GO:0140596 - TOM complex

References:

GO molecular function

GO:0140436 - mitochondrial signal sequence receptor activity

References:

GO:0008320 - transmembrane protein transporter activity

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02064MAS20MAS20Pfam
PR00351OM20RECEPTORMAS20PRINTS
G3DSA:1.20.960.10:FF:000002CATH-FunFam
G3DSA:1.20.960.10Tom20_dom_sfCATH-Gene3D
SSF47157Tom20_dom_sfSUPERFAMILY
PTHR12430MAS20PANTHER
PIRSF037707MAS20_rcptMAS20PIRSF
TIGR009853a0801s04tomMAS20NCBIFAM
CoilCOILS

Orthologs

References / Literature

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83