protein coding gene - sfc1 (SPAC6F12.11c) - transcription factor TFIIIC complex A box associated subunit Sfc1

Gene summary

Standard name: sfc1
Systematic ID: SPAC6F12.11c
Product: transcription factor TFIIIC complex A box associated subunit Sfc1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O14229
ORFeome ID: 23/23H02
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 1333347..1335333 reverse strand

Annotation

GO biological process

GO:0042791 - 5S class rRNA transcription by RNA polymerase III

References:

GO_REF:0000033

GO:0006384 - transcription initiation at RNA polymerase III promoter

References:

PMID:10906331

GO cellular component

GO:0005737 - cytoplasm

References:

PMID:16823372

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

GO_REF:0000051

GO:0000127 - transcription factor TFIIIC complex

References:

GO molecular function

GO:0043035 - chromatin insulator sequence binding

References:

PMID:16751097

GO:0000992 - RNA polymerase III cis-regulatory region sequence-specific DNA binding

References:

PMID:23921640

GO:0000995 - RNA polymerase III general transcription initiation factor activity

References:

PMID:10906331

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:29996109

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:23101633

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

PMID:23697806

Genotypes:

sfc1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

sfc1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF09734	Tau95	TF_IIIC_su-5_HTH	PFAM
PF17682	Tau95_N	Tfc1/Sfc1_N	PFAM
G3DSA:3.30.200.160	TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain	TFIIIC_tauA_Sfc1	GENE3D
PTHR13230	GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5	TF_IIIC_Tfc1/Sfc1	PANTHER
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Negative-Polyelectrolyte	disorder_prediction		MOBIDB-Negative-Polyelectrolyte
mobidb-lite-Polar	disorder_prediction		MOBIDB-Polar

Orthologs

GTF3C5 (HGNC:4668) Homo sapiens
sfc1 (SJAG_03354) Schizosaccharomyces japonicus
TFC1 (YBR123C) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26257282 - Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.: Iwasaki O et al. Mol Cell 2015 Sep 03;59(5):755-67
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.: Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
GO_REF:0000051 - S. pombe keyword mapping
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:16751097 - A role for TFIIIC transcription factor complex in genome organization.: Noma K et al. Cell 2006 Jun 02;125(5):859-72
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.: Li J et al. Nat Commun 2019 Mar 01;10(1):1002
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22540037 - Predicting the fission yeast protein interaction network.: Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:23921640 - RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74.: Taylor NM et al. Nucleic Acids Res 2013 Oct;41(19):9183-96
PMID:10906331 - Isolation and cloning of four subunits of a fission yeast TFIIIC complex that includes an ortholog of the human regulatory protein TFIIICbeta.: Huang Y et al. J Biol Chem 2000 Oct 06;275(40):31480-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6