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protein coding gene - par2 (SPAC6F12.12) - serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par2

Gene summary

Standard name
par2
Systematic ID
SPAC6F12.12
Product
serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
pbp2
UniProt ID
P78759
ORFeome ID
46/46F01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1335503..1338402 forward strand

Annotation

Complementation

PBO:0017584 - functionally complements S. cerevisiae RTS1

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Disease association

MONDO:0014602 - Houge-Janssens syndrome 1

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MONDO:0978293 - Houge-Janssens syndrome 4

References:

GO biological process

GO:1902426 - deactivation of mitotic spindle assembly checkpoint

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GO:0051177 - meiotic sister chromatid cohesion

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GO:0031030 - negative regulation of septation initiation signaling

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GO cellular component

GO:0032153 - cell division site

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GO:0051286 - cell tip

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GO:0005737 - cytoplasm

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GO:0000159 - protein phosphatase type 2A complex

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GO molecular function

GO:0072542 - protein phosphatase activator activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0003165 - cut with abnormal chromosome segregation

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0005727 - decreased rate of deactivation of mitotic spindle assembly checkpoint

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Genotypes:

FYPO:0006559 - delayed onset of mitotic spindle disassembly

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Genotypes:

FYPO:0006023 - elongated multinucleate multiseptate vegetative cell, irregular septum position

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Genotypes:

FYPO:0000155 - increased flocculation

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Genotypes:

FYPO:0000650 - increased septation index

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Genotypes:

FYPO:0003536 - increased septation index in stationary phase

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Genotypes:

FYPO:0002024 - inviable elongated multinucleate aseptate vegetative cell

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001387 - loss of viability at high temperature

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Genotypes:

FYPO:0003903 - loss of viability at low temperature

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Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

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Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

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Genotypes:

FYPO:0001254 - multinucleate multiseptate vegetative cell, septa grouped

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Genotypes:

FYPO:0004297 - multiseptate cell in stationary phase

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Genotypes:

FYPO:0000118 - multiseptate vegetative cell

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Genotypes:

FYPO:0001022 - normal growth during cellular response to high osmolarity

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Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0001966 - sensitive to aculeacin A

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Genotypes:

FYPO:0000094 - sensitive to benomyl

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Genotypes:

FYPO:0000098 - sensitive to calcium

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Genotypes:

FYPO:0000105 - sensitive to cyclosporin A

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0000271 - sensitive to salt stress

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Genotypes:

FYPO:0000112 - sensitive to sorbitol

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Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000021 - protein present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0005119 - altered protein binding specificity

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Genotypes:

FYPO:0005727 - decreased rate of deactivation of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0001758 - increased protein phosphatase activity

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Genotypes:

FYPO:0003536 - increased septation index in stationary phase

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

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Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

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Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

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Genotypes:

FYPO:0000961 - normal growth on sorbitol

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Genotypes:

FYPO:0001147 - normal mating efficiency

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Genotypes:

FYPO:0003176 - normal meiotic chromosome segregation

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Genotypes:

FYPO:0001903 - normal septation index

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Genotypes:

FYPO:0002253 - normal septum location

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0005969 - resistance to magnesium chloride

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002380 - viable spheroid vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF01603B56PP2A_B56PFAM
G3DSA:1.25.10.10:FF:000331FUNFAM
SSF48371ARM repeatARM-type_foldSUPERFAMILY
G3DSA:1.25.10.10ARM-likeGENE3D
PTHR10257SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT BPP2A_B56PANTHER
PIRSF028043PP2A_B56PP2A_B56PIRSF
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:11514436 - Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2.
Jiang W et al. Genetics 2001 Aug;158(4):1413-29
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:36006032 - Analysis of the potential role of fission yeast PP2A in spindle assembly checkpoint inactivation.
Deng DJ et al. FASEB J 2022 Sep;36(9):e22524
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25487150 - A PP1-PP2A phosphatase relay controls mitotic progression.
Grallert A et al. Nature 2015 Jan 01;517(7532):94-98
PMID:11380623 - Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin.
Tanabe O et al. Genes Cells 2001 May;6(5):455-73
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:10757751 - Isolation and characterization of par1(+) and par2(+): two Schizosaccharomyces pombe genes encoding B' subunits of protein phosphatase 2A.
Jiang W et al. Genetics 2000 Mar;154(3):1025-38
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:16415366 - A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.
Jin QW et al. Genetics 2006 Apr;172(4):2101-12
PMID:16541024 - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG et al. Nature 2006 May 04;441(7089):53-61
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514