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protein coding gene - fps1 (SPAC6F12.13c) - farnesyltranstransferase/ geranyltranstransferase Fps1

Gene summary

Standard name
fps1
Systematic ID
SPAC6F12.13c
Product
farnesyltranstransferase/ geranyltranstransferase Fps1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14230
ORFeome ID
44/44A12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1338365..1339932 reverse strand

Annotation

Complementation

PBO:0018229 - functionally complemented by S. cerevisiae ERG20

References:

PBO:0018231 - functionally complements E. coli ispA

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PBO:0018230 - functionally complements S. cerevisiae BTS1

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PBO:0000917 - functionally complements S. cerevisiae ERG20

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Disease association

MONDO:0014713 - porokeratosis 9, multiple types

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GO biological process

GO:0033386 - geranylgeranyl diphosphate biosynthetic process

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GO:0045337 - trans, trans-farnesyl diphosphate biosynthetic process

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005783 - endoplasmic reticulum

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GO:0005634 - nucleus

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GO molecular function

GO:0004337 - (2E,6E)-farnesyl diphosphate synthase activity

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GO:0004311 - geranylgeranyl diphosphate synthase activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0004778 - decreased farnesyltranstransferase activity

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Genotypes:

FYPO:0000590 - normal sporulation

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0004779 - normal farnesyltranstransferase activity

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00348polyprenyl_syntPolyprenyl_syntPfam
cd00685Trans_IPPS_HTPolyprenyl_syntCDD
PS00444POLYPRENYL_SYNTHASE_2Polyprenyl_synt_CSPROSITE patterns
PS00723POLYPRENYL_SYNTHASE_1Polyprenyl_synt_CSPROSITE patterns
G3DSA:1.10.600.10:FF:000006CATH-FunFam
G3DSA:1.10.600.10Isoprenoid_synthase_dom_sfCATH-Gene3D
SSF48576Isoprenoid_synthase_dom_sfSUPERFAMILY
PTHR11525FPS1-likePANTHER
SFLDG01017Polyprenyl_Transferase_LikeSFLD
SFLDS00005Isoprenoid_Synthase_Type_ISFLD

Orthologs

References / Literature

PMID:17596513 - Geranylgeranyl diphosphate synthase in fission yeast is a heteromer of farnesyl diphosphate synthase (FPS), Fps1, and an FPS-like protein, Spo9, essential for sporulation.
Ye Y et al. Mol Biol Cell 2007 Sep;18(9):3568-81
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.
Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:19366728 - Genetic control of cellular quiescence in S. pombe.
Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7