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protein coding gene - pof5 (SPAC6F6.02c) - F-box protein Pof5

Gene summary

Standard name
pof5
Systematic ID
SPAC6F6.02c
Product
F-box protein Pof5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14235
ORFeome ID
15/15H08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2732373..2733860 reverse strand

Annotation

GO biological process

GO:0006289 - nucleotide-excision repair

References:

GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0000113 - nucleotide-excision repair factor 4 complex

References:

GO:0019005 - SCF ubiquitin ligase complex

References:

GO molecular function

GO:1990756 - ubiquitin-like ligase-substrate adaptor activity

References:

Protein features

PBO:0111823 - F-box protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0005193 - resistance to torin1

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Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
G3DSA:3.80.10.10LRR_dom_sfCATH-Gene3D
SSF52047SUPERFAMILY

Orthologs

References / Literature

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:15147268 - Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.
Lehmann A et al. Genes Cells 2004 May;9(5):367-82
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Liu NN et al. Cell Res 2010 Aug;20(8):963-5
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:11820777 - Isolation and characterization of a novel F-box protein Pof10 in fission yeast.
Ikebe C et al. Biochem Biophys Res Commun 2002 Feb 08;290(5):1399-407
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23535663 - CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.
Wu S et al. Nat Commun 2013;4:1642