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protein coding gene - rax2 (SPAC6F6.06c) - cell polarity factor Rax2

Gene summary

Standard name
rax2
Systematic ID
SPAC6F6.06c
Product
cell polarity factor Rax2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14239
ORFeome ID
30/30E03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2741001..2745210 reverse strand

Annotation

GO biological process

GO:0061572 - actin filament bundle organization

References:

GO:0061245 - establishment or maintenance of bipolar cell polarity

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GO cellular component

GO:1902929 - plasma membrane of growing cell tip

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Modification

MOD:00006 - N-glycosylated residue

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Multi-locus phenotype

FYPO:0003314 - activation of monopolar cell growth at new end

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Genotypes:

FYPO:0001019 - monopolar actin cortical patch localization during vegetative growth

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

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SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003315 - actin cables absent from cell

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Genotypes:

FYPO:0003314 - activation of monopolar cell growth at new end

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Genotypes:

FYPO:0003317 - decreased protein localization to growing cell tip, with protein distributed in plasma membrane or cortex

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Genotypes:

FYPO:0009052 - increased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0001294 - normal actin cortical patch localization

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Genotypes:

FYPO:0002022 - normal actin cortical patch morphology

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Genotypes:

FYPO:0001400 - normal interphase microtubules

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Genotypes:

FYPO:0001147 - normal mating efficiency

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF12768Rax2Rax2-like_CPfam
PF20842Rax2_2Rax2-like_secondPfam
PF20843Rax2_3Rax2-like_thirdPfam
PTHR31778PANTHER
Transmembrane alpha helixDeepTMHMM
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:17085965 - Function of rax2p in the polarized growth of fission yeast.
Choi E et al. Mol Cells 2006 Oct 31;22(2):146-53
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:42687857 - Memory of growth promotes early Ras GTPase activation to establish dominance of inherited cell ends in S. pombe.
Vickers WH et al. J Cell Sci 2026 Sep 03;
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183