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protein coding gene - ypt5 (SPAC6F6.15) - GTPase Ypt5

Gene summary

Standard name
ypt5
Systematic ID
SPAC6F6.15
Product
GTPase Ypt5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P36586
ORFeome ID
32/32D12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2762223..2763604 forward strand

Annotation

Complementation

PBO:0016533 - functionally complemented by canine rab5

References:

PBO:0001716 - functionally complemented by mammalian rab5

References:

GO biological process

GO:0034058 - endosomal vesicle fusion

References:

GO:0006886 - intracellular protein transport

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0031901 - early endosome membrane

References:

GO:0005770 - late endosome

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GO:0005634 - nucleus

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GO molecular function

GO:0005525 - GTP binding

References:

GO:0003924 - GTPase activity

References:

GO:0030674 - protein-macromolecule adaptor activity

References:

Modification

MOD:00441 - geranylgeranylated residue

References:

MOD:00114 - L-cysteine methyl ester

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:01061 - S-carboxymethyl-L-cysteine

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MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111842 - Rab subfamily

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001001 - abnormal cell cycle arrest at mitotic G2/M phase transition during nitrogen starvation

References:

Genotypes:

FYPO:0001002 - abolished cell division prior to G0 entry

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Genotypes:

FYPO:0001283 - decreased protein level during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

Genotypes:

FYPO:0000951 - inviable small vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002451 - inviable vegetative cell with abnormal cell shape

References:

Genotypes:

FYPO:0001178 - loss of viability upon nitrogen starvation

References:

Genotypes:

FYPO:0000997 - pear-shaped cell during nitrogen starvation

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00071RasSmall_GTPasePFAM
cd01860Rab5_relatedCDD
PS51420RHOPROSITE_PROFILES
PS51421RASSmall_GTPasePROSITE_PROFILES
PS51419RABPROSITE_PROFILES
SM00176ran_sub_2SMART
SM00174rho_sub_3Small_GTPaseSMART
SM00175rab_sub_5SMART
SM00173ras_sub_4SMART
PR00449RASTRNSFRMNGPRINTS
G3DSA:3.40.50.300:FF:000464FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR47978PANTHER
CoilCoilCOILS
TIGR00231small_GTPSmall_GTP-bdNCBIFAM

Orthologs

References / Literature

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:8226998 - Post-translational processing of Schizosaccharomyces pombe YPT5 protein. In vitro and in vivo analysis of processing mutants.
Giannakouros T et al. J Biol Chem 1993 Nov 15;268(32):24467-74
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:19366728 - Genetic control of cellular quiescence in S. pombe.
Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29
PMID:15548596 - Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.
Webb CJ et al. Mol Biol Cell 2005 Feb;16(2):584-96
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:8374169 - Schizosaccharomyces pombe ypt5: a homologue of the rab5 endosome fusion regulator.
Armstrong J et al. Mol Biol Cell 1993 Jun;4(6):583-92
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
PMID:1597466 - Post-translational processing of Schizosaccharomyces pombe YPT proteins.
Newman CM et al. J Biol Chem 1992 Jun 05;267(16):11329-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87