protein coding gene - rif1 (SPAC6F6.17) - telomere length regulator protein Rif1

Gene summary

Standard name

rif1

Systematic ID

SPAC6F6.17

Product

telomere length regulator protein Rif1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

tap1, tap11, SPAPJ736.01

UniProt ID

Q96UP3

ORFeome ID

30/30G03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2766273..2770704 forward strand

Annotation

Protein features

Orthologs

• RIF1 (HGNC:23207) Homo sapiens
• rif1 (SJAG_01377) Schizosaccharomyces japonicus
• RIF1 (YBR275C) Saccharomyces cerevisiae

References / Literature

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:29774234 - The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.

Matmati S et al. Sci Adv 2018 May;4(5):eaar2740

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:29422501 - LARP7 family proteins have conserved function in telomerase assembly.

Collopy LC et al. Nat Commun 2018 Feb 08;9(1):557

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23936074 - Telomeric repeats facilitate CENP-A(Cnp1) incorporation via telomere binding proteins.

Castillo AG et al. PLoS One 2013;8(7):e69673

PMID:28228545 - Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB.

Upadhyay U et al. Mol Biol Cell 2017 Apr 15;28(8):1132-1146

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:24656819 - Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity.

Davé A et al. Cell Rep 2014 Apr 10;7(1):53-61

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26436827 - Rif1 binds to G quadruplexes and suppresses replication over long distances.

Kanoh Y et al. Nat Struct Mol Biol 2015 Nov;22(11):889-97

PMID:26201080 - The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.

Zech J et al. PLoS One 2015;10(7):e0132595

PMID:27473316 - Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Ranatunga NS et al. G3 (Bethesda) 2016 Oct 13;6(10):3049-3063

PMID:25398909 - Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels.

Lorenzi LE et al. EMBO J 2015 Jan 02;34(1):115-29

PMID:29422503 - LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.

Mennie AK et al. Nat Commun 2018 Feb 08;9(1):586

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:11676925 - spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast.

Kanoh J et al. Curr Biol 2001 Oct 16;11(20):1624-30

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:27066066 - Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in Yeasts.

Mattarocci S et al. Front Genet 2016;7:45

PMID:17209013 - Role of SUMO in the dynamics of telomere maintenance in fission yeast.

Xhemalce B et al. Proc Natl Acad Sci U S A 2007 Jan 16;104(3):893-8

PMID:22279046 - Rif1 is a global regulator of timing of replication origin firing in fission yeast.

Hayano M et al. Genes Dev 2012 Jan 15;26(2):137-50

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:22987637 - Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast.

Tazumi A et al. Genes Dev 2012 Sep 15;26(18):2050-62

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Garg M et al. EMBO Rep 2014 Aug;15(8):871-7

PMID:16096639 - Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.

Miller KM et al. EMBO J 2005 Sep 07;24(17):3128-35

PMID:27320927 - Rif1 Regulates the Fate of DNA Entanglements during Mitosis.

Zaaijer S et al. Cell Rep 2016 Jun 28;16(1):148-160

PMID:25245948 - Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.

Wang J et al. Nucleic Acids Res 2014 Oct;42(18):11419-32

PMID:28180297 - Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.

Takikawa M et al. Nucleic Acids Res 2017 Feb 17;45(3):1255-1269

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:29216371 - Fission yeast Ccq1 is a modulator of telomerase activity.

Armstrong CA et al. Nucleic Acids Res 2018 Jan 25;46(2):704-716

PMID:32586625 - Detection of cellular G-quadruplex by using a loop structure as a structural determinant.

Masai H et al. Biochem Biophys Res Commun 2020 Oct 08;531(1):75-83

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:41201383 - Combinatorial Analyses of Pre-mRNA Splicing-Defective Mutants Reveal Differential Quantitative Requirements for Shelterin in Distinct Telomere Functions.

Takeuchi M et al. Genes Cells 2025 Nov;30(6):e70064

PMID:26990647 - Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.

Gadaleta MC et al. PLoS Genet 2016 Mar;12(3):e1005943

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:31289327 - Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins.

Hasegawa Y et al. Sci Rep 2019 Jul 09;9(1):9946

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:31269446 - CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Vo TV et al. Cell Rep 2019 Jul 02;28(1):267-281.e5

GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.

PMID:28366642 - Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.

Shetty A et al. Mol Cell 2017 Apr 06;66(1):77-88.e5

PMID:30796050 - Ssu72 phosphatase is a conserved telomere replication terminator.

Escandell JM et al. EMBO J 2019 Apr 01;38(7)

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30217821 - Molecular architecture of G-quadruplex structures generated on duplex Rif1-binding sequences.

Masai H et al. J Biol Chem 2018 Nov 02;293(44):17033-17049