protein coding gene - sap34 (SPAC6F6.19) - RNA binding splicing factor, human GPATCH11 ortholog, Sap34

Gene summary

Standard name: sap34
Systematic ID: SPAC6F6.19
Product: RNA binding splicing factor, human GPATCH11 ortholog, Sap34
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: C6Y4A5
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 2759155..2760356 reverse strand

Annotation

GO cellular component

GO:0005634 - nucleus

References:

GO_REF:0000024

GO molecular function

GO:0003723 - RNA binding

References:

GO_REF:0000024

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:39367033

Protein features

PBO:0111798 - G-patch domain

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0004167 - increased cell population growth on glycerol carbon source

References:

PMID:37787768

Genotypes:

sap34delta

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

sap34delta

FYPO:0007931 - sensitive to egtazic acid

References:

PMID:37787768

Genotypes:

sap34delta

FYPO:0001719 - sensitive to lithium

References:

PMID:37787768

Genotypes:

sap34delta

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

sap34delta

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

sap34delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000108 - frameshifted

References:

PMID:42260140

PBO:0000082 - new gene

References:

PMID:18488015

Protein features

ID	Name	InterPro name	DB name
PF13821	DUF4187	DUF4187	Pfam
SM01173	DUF4187	DUF4187	SMART
PTHR21032		GPATCH11	PANTHER
mobidb-lite-Disorder	disorder_prediction		MobiDB-Disorder
mobidb-lite-Negative-Polyelectrolyte	disorder_prediction		MobiDB-Negative-Polyelectrolyte
mobidb-lite-Polar	disorder_prediction		MobiDB-Polar
mobidb-lite-Polyampholyte	disorder_prediction		MobiDB-Polyampholyte

Orthologs

GPATCH11 (HGNC:26768) Homo sapiens
sap34 (SJAG_01380) Schizosaccharomyces japonicus
CMG1 (YLR271W) Saccharomyces cerevisiae

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.: Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:42260140 - GPATCH11 ortholog Sap34 regulates pre-mRNA splicing by interacting with early spliceosomal complexes in Schizosaccharomyces pombe.: Cipakova I et al. Sci Rep 2026 Jun 08;
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12