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protein coding gene - trs120 (SPAC6G10.05c) - TRAPP II complex subunit Trs120

Gene summary

Standard name
trs120
Systematic ID
SPAC6G10.05c
Product
TRAPP II complex subunit Trs120
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14251
ORFeome ID
39/39C05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3222368..3226277 reverse strand

Annotation

Disease association

MONDO:0013173 - intellectual disability, autosomal recessive 13

References:

GO biological process

GO:0006893 - Golgi to plasma membrane transport

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GO:0006891 - intra-Golgi vesicle-mediated transport

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GO:0044091 - membrane biogenesis

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GO cellular component

GO:0032153 - cell division site

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GO:0005801 - cis-Golgi network

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GO:0032154 - cleavage furrow

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GO:0005829 - cytosol

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GO:0035838 - growing cell tip

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GO:0005802 - trans-Golgi network

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GO:1990071 - TRAPPII protein complex

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GO molecular function

GO:0043495 - protein-membrane adaptor activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0000134 - branched, elongated, multiseptate cell

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Genotypes:

FYPO:0000223 - elongated multiseptate vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001364 - abnormal actomyosin contractile ring contraction

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Genotypes:

FYPO:0003440 - cell lysis during cytokinesis

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Genotypes:

FYPO:0004572 - decreased exocytosis during vegetative growth

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Genotypes:

FYPO:0002869 - decreased protein localization to cell division site

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Genotypes:

FYPO:0001586 - decreased protein localization to cell tip during vegetative growth

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Genotypes:

FYPO:0005551 - decreased protein localization to cleavage furrow

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Genotypes:

FYPO:0005552 - decreased protein localization to cleavage furrow rim

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Genotypes:

FYPO:0002087 - exocytic vesicles present in increased numbers at cell tip during mitotic interphase

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Genotypes:

FYPO:0002088 - exocytic vesicles present in increased numbers at septum during septum assembly

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Genotypes:

FYPO:0003213 - explosive cytokinetic cell separation resulting in vegetative cell lysis

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Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

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Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001368 - normal actomyosin contractile ring assembly

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Genotypes:

FYPO:0000644 - normal protein localization during vegetative growth

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Genotypes:

FYPO:0001904 - premature actomyosin contractile ring disassembly

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Genotypes:

FYPO:0002240 - swollen septated spheroid vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF08626TRAPPC9-Trs120Trs120_TRAPPC9_NPfam
PF26251TPR_TRAPPC9-Trs120TPR_TRAPPC9_Trs120Pfam
PF26254Ig_TRAPPC9-Trs120_1stIg_TRAPPC9_Trs120_1stPfam
PF26280Ig_TRAPPC9-Trs120_2ndPfam
PF26282Ig_TRAPPC9-Trs120_3rdIg_TRAPPC9_Trs120_3rdPfam
PF26283Ig_TRAPPC9-Trs120_4thIg_TRAPPC9_Trs120_4thPfam
PTHR21512Trs120_TRAPPC9PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity

Orthologs

References / Literature

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:41171630 - Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis.
Singh D et al. Elife 2025 Oct 31;13
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:27082518 - Roles of the TRAPP-II Complex and the Exocyst in Membrane Deposition during Fission Yeast Cytokinesis.
Wang N et al. PLoS Biol 2016 Apr;14(4):e1002437
PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.
Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
GO_REF:0000051 - S. pombe keyword mapping
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:41144523 - The Ync13-Rga7-Rng10 complex selectively coordinates secretory vesicle trafficking and secondary septum formation during cytokinesis.
Zhang S et al. PLoS Biol 2025 Oct 27;23(10):e3003466
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31