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protein coding gene - spo7 (SPAC6G9.04) - ArfGEF Spo7

Gene summary

Standard name
spo7
Systematic ID
SPAC6G9.04
Product
ArfGEF Spo7
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug79
UniProt ID
Q92349
ORFeome ID
48/48F06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3247759..3252881 forward strand

Annotation

Comment

PBO:0012243 - promoter contains FLEX elelment

References:

GO biological process

GO:0032120 - ascospore-type prospore membrane formation

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GO:0031322 - ascospore-type prospore-specific spindle pole body remodeling

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GO:0070583 - spore membrane bending pathway

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GO cellular component

GO:0005737 - cytoplasm

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GO:0035974 - meiotic spindle pole body

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GO:0072686 - mitotic spindle

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GO:0005635 - nuclear envelope

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GO:0034399 - nuclear periphery

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GO molecular function

GO:0005085 - guanyl-nucleotide exchange factor activity

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GO:0032266 - phosphatidylinositol-3-phosphate binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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Protein features

PBO:0111759 - pleckstrin homology domain

Qualitative gene expression

PomGeneEx:0000015 - RNA absent

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PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

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Genotypes:

FYPO:0003139 - abnormal sporulation resulting in formation of ascus containing anucleate spores

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Genotypes:

FYPO:0001915 - abolished prospore membrane formation

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Genotypes:

FYPO:0003542 - abolished protein localization to meiotic spindle pole body

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0002488 - cell lysis

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0004295 - multiseptate cell

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Genotypes:

FYPO:0003541 - normal protein localization to meiotic spindle pole body

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0006680 - sensitive to bisphenol A

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Genotypes:

FYPO:0001701 - sensitive to bortezomib

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Subunit composition

PBO:0015212 - homomeric(2)

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Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00169PHPH_domainPfam
PF01369Sec7Sec7_domPfam
cd00821PHCDD
PS50003PH_DOMAINPH_domainPROSITE profiles
SM00233PHPH_domainSMART
G3DSA:2.30.29.30PH-like_dom_sfCATH-Gene3D
SSF48425Sec7_dom_sfSUPERFAMILY
SSF50729SUPERFAMILY
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:22146723 - Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.
Ikebe C et al. Biosci Biotechnol Biochem 2011;75(12):2364-70
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
GO_REF:0000002 - Comments
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.
Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62
PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.
Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:27630265 - The exocytic Rabs Ypt3 and Ypt2 regulate the early step of biogenesis of the spore plasma membrane in fission yeast.
Imada K et al. Mol Biol Cell 2016 Nov 01;27(21):3317-3328
PMID:21775631 - The fission yeast pleckstrin homology domain protein Spo7 is essential for initiation of forespore membrane assembly and spore morphogenesis.
Nakamura-Kubo M et al. Mol Biol Cell 2011 Sep;22(18):3442-55
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Takeda K et al. PLoS One 2011;6(7):e22021
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623