protein coding gene - pcp1 (SPAC6G9.06c) - gamma tubulin complex linker, pericentrin/kendrin Pcp1

Gene summary

Standard name

pcp1

Systematic ID

SPAC6G9.06c

Product

gamma tubulin complex linker, pericentrin/kendrin Pcp1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q92351

ORFeome ID

39/39B07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3254401..3258280 reverse strand

Annotation

Protein features

Orthologs

• PCNT (HGNC:16068) Homo sapiens
• pcp1 (SJAG_02246) Schizosaccharomyces japonicus
• SPC110 (YDR356W) Saccharomyces cerevisiae

References / Literature

PMID:38985524 - The core spindle pole body scaffold Ppc89 links the pericentrin ortholog Pcp1 to the fission yeast spindle pole body via an evolutionarily conserved interface.

Chen JS et al. Mol Biol Cell 2024 Jul 10;:mbcE24050220

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:22438582 - Spindle pole body components are reorganized during fission yeast meiosis.

Ohta M et al. Mol Biol Cell 2012 May;23(10):1799-811

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:16775007 - Ppc89 links multiple proteins, including the septation initiation network, to the core of the fission yeast spindle-pole body.

Rosenberg JA et al. Mol Biol Cell 2006 Sep;17(9):3793-805

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:15992541 - The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification.

Jin Y et al. Dev Cell 2005 Jul;9(1):63-73

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.

Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477

PMID:20833892 - Schizosaccharomyces pombe calmodulin, Cam1, plays a crucial role in sporulation by recruiting and stabilizing the spindle pole body components responsible for assembly of the forespore membrane.

Itadani A et al. Eukaryot Cell 2010 Dec;9(12):1925-35

PMID:15004232 - Identification and characterization of two novel proteins affecting fission yeast gamma-tubulin complex function.

Venkatram S et al. Mol Biol Cell 2004 May;15(5):2287-301

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:27053664 - Synergistic role of fission yeast Alp16GCP6 and Mzt1MOZART1 in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly.

Masuda H et al. Mol Biol Cell 2016 Jun 01;27(11):1753-63

PMID:27889481 - Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.

Fernández-Álvarez A et al. Dev Cell 2016 Dec 05;39(5):544-559

PMID:24937146 - Targeting Alp7/TACC to the spindle pole body is essential for mitotic spindle assembly in fission yeast.

Tang NH et al. FEBS Lett 2014 Aug 25;588(17):2814-21

PMID:21233285 - Spatiotemporal regulations of Wee1 at the G2/M transition.

Masuda H et al. Mol Biol Cell 2011 Mar 01;22(5):555-69

PMID:11901107 - Fission yeast mutants affecting telomere clustering and meiosis-specific spindle pole body integrity.

Jin Y et al. Genetics 2002 Mar;160(3):861-76

PMID:31042107 - Generation of temperature sensitive mutations with error-prone PCR in a gene encoding a component of the spindle pole body in fission yeast.

Tang NH et al. Biosci Biotechnol Biochem 2019 Sep;83(9):1717-1720

PMID:19942852 - Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation.

Fong CS et al. EMBO J 2010 Jan 06;29(1):120-30

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:11864908 - Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe.

Flory MR et al. Cell Growth Differ 2002 Feb;13(2):47-58

PMID:18600047 - Genome-wide identification of haploinsufficiency in fission yeast.

Baek ST et al. J Microbiol Biotechnol 2008 Jun;18(6):1059-63

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PB_REF:0000003 - Disease Association Curation

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:14711417 - A potential tension-sensing mechanism that ensures timely anaphase onset upon metaphase spindle orientation.

Rajagopalan S et al. Curr Biol 2004 Jan 06;14(1):69-74

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:24963130 - The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body.

Wälde S et al. J Cell Sci 2014 Aug 15;127(Pt 16):3625-40

PMID:26613727 - Regulation of mitochondrial inner membrane fusion: divergent evolution with similar solutions?

Wagener J Curr Genet 2016 May;62(2):291-4

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:15546621 - An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome.

Flory MR et al. Mol Cell 2004 Nov 19;16(4):619-30

PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.

Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601

PMID:28619713 - Molecular model of fission yeast centrosome assembly determined by superresolution imaging.

Bestul AJ et al. J Cell Biol 2017 Aug 07;216(8):2409-2424

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:39471327 - New mutations in the core Schizosaccharomyces pombe spindle pole body scaffold Ppc89 reveal separable functions in regulating cell division.

Hanna SM et al. G3 (Bethesda) 2024 Oct 29;

PMID:24055157 - CK1 is required for a mitotic checkpoint that delays cytokinesis.

Johnson AE et al. Curr Biol 2013 Oct 07;23(19):1920-6