protein coding gene - trx1 (SPAC7D4.07c) - cytosolic thioredoxin Trx1

Gene summary

Standard name

trx1

Systematic ID

SPAC7D4.07c

Product

cytosolic thioredoxin Trx1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O14463

ORFeome ID

01/01F01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2625313..2625855 forward strand

Annotation

Protein features

Orthologs

• TXN (HGNC:12435) Homo sapiens
• trx1 (SJAG_04953) Schizosaccharomyces japonicus
• TRX2 (YGR209C) Saccharomyces cerevisiae
• TRX1 (YLR043C) Saccharomyces cerevisiae

References / Literature

PMID:11267679 - Characterization and regulation of Schizosaccharomyces pombe gene encoding thioredoxin.

Cho Y et al. Biochim Biophys Acta 2001 Mar 19;1518(1-2):194-9

PMID:16950927 - Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast.

Song JY et al. Eukaryot Cell 2006 Nov;5(11):1857-65

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:24268782 - A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein.

Brown JD et al. Cell Rep 2013 Dec 12;5(5):1425-35

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:18162174 - Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast.

Lee SY et al. Biochem Biophys Res Commun 2008 Feb 29;367(1):67-71

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:12018855 - Pap1-mediated regulation of thioredoxin gene from Schizosaccharomyces pombe.

Cho YW et al. Mol Cells 2002 Apr 30;13(2):315-21

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:10628977 - Isolation and characterization of Nrf1p, a novel negative regulator of the Cdc42p GTPase in Schizosaccharomyces pombe.

Murray JM et al. Genetics 2000 Jan;154(1):155-65

PMID:27005325 - Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions.

Pluskal T et al. Genes Cells 2016 Jun;21(6):530-42

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:37572670 - A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms.

Cao M et al. Mol Cell 2023 Sep 07;83(17):3140-3154.e7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:18758731 - The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.

Song JY et al. J Microbiol 2008 Aug;46(4):408-14

PMID:23121505 - Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach.

García-Santamarina S et al. Antioxid Redox Signal 2013 May 01;18(13):1549-56

PMID:28640807 - Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.

Boronat S et al. PLoS Genet 2017 Jun;13(6):e1006858

PMID:25552606 - Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. G3 (Bethesda) 2014 Dec 31;5(3):361-70

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:24118096 - Methionine sulphoxide reductases revisited: free methionine as a primary target of H₂O₂stress in auxotrophic fission yeast.

García-Santamarina S et al. Mol Microbiol 2013 Dec;90(5):1113-24

PMID:29859088 - Using in vivo oxidation status of one- and two-component redox relays to determine H 2 O 2 levels linked to signaling and toxicity.

Domènech A et al. BMC Biol 2018 Jun 01;16(1):61

PMID:24316080 - Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle.

Calvo IA et al. Cell Rep 2013 Dec 12;5(5):1413-24

PMID:22245228 - Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.

Day AM et al. Mol Cell 2012 Feb 10;45(3):398-408

PMID:12020831 - Characterization and regulation of a second gene encoding thioredoxin from the fission yeast.

Lee YJ et al. Biochim Biophys Acta 2002 May 03;1575(1-3):143-7

PMID:21091378 - Txl1 and Txc1 are co-factors of the 26S proteasome in fission yeast.

Andersen KM et al. Antioxid Redox Signal 2011 May 01;14(9):1601-8

PMID:24155978 - Possible involvement of nitric oxide and reactive oxygen species in glucose deprivation-induced activation of transcription factor rst2.

Kato T et al. PLoS One 2013;8(10):e78012

PMID:17409354 - The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast.

Jara M et al. Mol Biol Cell 2007 Jun;18(6):2288-95

PMID:23115244 - Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.

Gabrielli N et al. J Biol Chem 2012 Dec 14;287(51):43042-51