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protein coding gene - dfg10 (SPAC7D4.09c) - ER polyprenol reductase Dfg10

Gene summary

Standard name
dfg10
Systematic ID
SPAC7D4.09c
Product
ER polyprenol reductase Dfg10
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14264
ORFeome ID
10/10F07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2622478..2623585 forward strand

Annotation

Disease association

MONDO:0015286 - congenital disorder of glycosylation

References:

MONDO:0012991 - Kahrizi syndrome

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0012885 - SRD5A3-congenital disorder of glycosylation

References:

GO biological process

GO:0043048 - dolichyl monophosphate biosynthetic process

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO molecular function

GO:0160198 - polyprenal reductase activity

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0006927 - decreased nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02544Steroid_dh3-oxo-5_a-steroid_4-DH_CPfam
PS50244S5A_REDUCTASEPROSITE profiles
G3DSA:1.20.120.1630CATH-Gene3D
PTHR14624Dfg10/SRD5A3PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

GO_REF:0000051 - S. pombe keyword mapping
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:30759079 - A systematic genetic screen identifies essential factors involved in nuclear size control.
Cantwell H et al. PLoS Genet 2019 Feb;15(2):e1007929
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000003 - Disease Association Curation
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.