protein coding gene - SPAC806.02c - CIA machinery CIA1/CFD1 fusion protein

Gene summary

Systematic ID: SPAC806.02c
Product: CIA machinery CIA1/CFD1 fusion protein
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UT57
ORFeome ID: 46/46A10
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 233032..235139 reverse strand

Annotation

Disease association

MONDO:0975806 - multiple mitochondrial dysfunctions syndrome 10

References:

PB_REF:0000006

GO biological process

GO:0016226 - iron-sulfur cluster assembly

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:1904564 - cytosolic [4Fe-4S] assembly scaffold complex

References:

PMID:34660592

GO:0097361 - cytosolic [4Fe-4S] assembly targeting complex

References:

GO_REF:0000002

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0051539 - 4 iron, 4 sulfur cluster binding

References:

GO_REF:0000002

GO:0005524 - ATP binding

References:

GO_REF:0000002

GO:0140663 - ATP-dependent FeS chaperone activity

References:

GO_REF:0000002

Genome organisation

PBO:0000228 - domain combination not observed in other organisms

PBO:0000229 - tandem fusion protein

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:21712547

MOD:00047 - O-phospho-L-threonine

References:

PMID:21712547

Protein features

PBO:0111751 - WD repeat protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

SPAC806.02cdelta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

SPAC806.02cdelta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

SPAC806.02cdelta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF00400	WD40	WD40_rpt	PFAM
PF10609	ParA	YlxH/NBP35	PFAM
cd02037	Mrp_NBP35	Mrp/NBP35_ATP-bd	CDD
cd00200	WD40		CDD
PS01215	MRP	Mrp-like_CS	PROSITE_PATTERNS
PS50082	WD_REPEATS_2	WD40_rpt	PROSITE_PROFILES
PS50294	WD_REPEATS_REGION		PROSITE_PROFILES
SM00320	WD40_4	WD40_rpt	SMART
G3DSA:3.40.50.300:FF:004040			FUNFAM
SSF50978	WD40 repeat-like	WD40_repeat_dom_sf	SUPERFAMILY
SSF52540	P-loop containing nucleoside triphosphate hydrolases	P-loop_NTPase	SUPERFAMILY
G3DSA:2.130.10.10		WD40/YVTN_repeat-like_dom_sf	GENE3D
G3DSA:3.40.50.300		P-loop_NTPase	GENE3D
PTHR23264	NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED	Mrp/NBP35_ATP-bd	PANTHER
MF_03039	NUBP2	NUBP2/Cfd1_eukaryotes	HAMAP
MF_02040	Mrp_NBP35	Mrp/NBP35_ATP-bd	HAMAP
MF_03037	ciao1	CIAO1/Cia1	HAMAP

Orthologs

CIAO1 (HGNC:14280) Homo sapiens
NUBP2 (HGNC:8042) Homo sapiens
SJAG_02895 Schizosaccharomyces japonicus
CIA1 (YDR267C) Saccharomyces cerevisiae
CFD1 (YIL003W) Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:34660592 - Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism.: Shi R et al. Front Cell Dev Biol 2021;9:735678
PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .: Budden AM et al. Elife 2023 Aug 24;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053