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protein coding gene - mod21 (SPAC806.08c) - gamma tubulin complex GCP5 subunit Mod21

Gene summary

Standard name
mod21
Systematic ID
SPAC806.08c
Product
gamma tubulin complex GCP5 subunit Mod21
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UT52
ORFeome ID
36/36H04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 248579..250926 reverse strand

Annotation

GO biological process

GO:0031122 - cytoplasmic microtubule organization

References:

GO:0051321 - meiotic cell cycle

References:

GO:0051415 - microtubule nucleation by interphase microtubule organizing center

References:

GO:0000278 - mitotic cell cycle

References:

GO:0051225 - spindle assembly

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0000923 - equatorial microtubule organizing center

References:

GO:0000931 - gamma-tubulin ring complex

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0051011 - microtubule minus-end binding

References:

GO:0140490 - microtubule nucleator activity

References:

Multi-locus phenotype

FYPO:0005699 - normal interphase microtubule nucleation from spindle pole body

References:

Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0003612 - viable spore population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001350 - abnormal microtubule cytoskeleton organization during vegetative growth

References:

Genotypes:

FYPO:0006336 - decreased mitotic microtubule nucleation

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF20685GCP5-Mod21_CPFAM
PF14609GCP5-Mod21_NMod21_NPFAM

Orthologs

References / Literature

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27053664 - Synergistic role of fission yeast Alp16GCP6 and Mzt1MOZART1 in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly.
Masuda H et al. Mol Biol Cell 2016 Jun 01;27(11):1753-63
PMID:21993292 - Microtubule nucleation by γ-tubulin complexes.
Kollman JM et al. Nat Rev Mol Cell Biol 2011 Oct 12;12(11):709-21
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21444751 - Microtubule stabilization in vivo by nucleation-incompetent γ-tubulin complex.
Anders A et al. J Cell Sci 2011 Apr 15;124(Pt 8):1207-13
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:17021256 - Noncore components of the fission yeast gamma-tubulin complex.
Anders A et al. Mol Biol Cell 2006 Dec;17(12):5075-93
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:32610137 - Promiscuous Binding of Microprotein Mozart1 to γ-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation.
Huang TL et al. Cell Rep 2020 Jun 30;31(13):107836
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)