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protein coding gene - cid13 (SPAC821.04c) - cytoplasmic poly(A) polymerase Cid13

Gene summary

Standard name
cid13
Systematic ID
SPAC821.04c
Product
cytoplasmic poly(A) polymerase Cid13
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UT49
ORFeome ID
45/45F11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 983567..987020 reverse strand

Annotation

GO biological process

GO:0070935 - 3'-UTR-mediated mRNA stabilization

References:

GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0003730 - mRNA 3'-UTR binding

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GO:1990817 - poly(A) RNA polymerase activity

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GO:0034061 - DNA polymerase activity

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Multi-locus phenotype

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

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Genotypes:

FYPO:0006203 - decreased cellular dATP level

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Genotypes:

FYPO:0002571 - decreased cellular dGTP level

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Genotypes:

FYPO:0002930 - decreased poly(A) tail length

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Genotypes:

FYPO:0002975 - decreased RNA level during cellular response to hydroxyurea

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Genotypes:

FYPO:0007845 - increased rate of RNA catabolic process during vegetative growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0001929 - normal cell cycle regulation during cellular response to hydroxyurea

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Genotypes:

FYPO:0002335 - normal chromatin silencing

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Genotypes:

FYPO:0006995 - normal chromatin silencing at centromere inner repeat

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

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Genotypes:

FYPO:0007921 - sensitive to benzamidine

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009084 - sensitive to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0000111 - sensitive to rapamycin

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002701 - sensitive to torin1

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0001491 - viable vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF03828PAP_assocPAP_assocPfam
PF22600MTPAP-like_centralMTPAP-like_centralPfam
cd05402NT_PAP_TUTaseCDD
G3DSA:1.10.1410.10:FF:000018CATH-FunFam
G3DSA:1.10.1410.10CATH-Gene3D
G3DSA:3.30.460.10NT_sfCATH-Gene3D
SSF81301NT_sfSUPERFAMILY
SSF81631SUPERFAMILY
PTHR12271PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMobiDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
GO_REF:0000051 - S. pombe keyword mapping
PMID:12218190 - Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest.
Read RL et al. Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12079-84
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:17512405 - RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing.
Bühler M et al. Cell 2007 May 18;129(4):707-21
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:17651922 - Identification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction.
Oki M et al. Gene 2007 Oct 01;400(1-2):114-21
PMID:12062100 - Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.
Saitoh S et al. Cell 2002 May 31;109(5):563-73
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7