protein coding gene - eng1 (SPAC821.09) - cell septum surface endo-1,3-beta-glucanase Eng1

Gene summary

Standard name

eng1

Systematic ID

SPAC821.09

Product

cell septum surface endo-1,3-beta-glucanase Eng1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9UT45

ORFeome ID

29/29H08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 998632..1002361 forward strand

Annotation

Protein features

Orthologs

• eng1 (SJAG_00667) Schizosaccharomyces japonicus
• ACF2 (YLR144C) Saccharomyces cerevisiae
• DSE4 (YNR067C) Saccharomyces cerevisiae

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:12665550 - The endo-beta-1,3-glucanase eng1p is required for dissolution of the primary septum during cell separation in Schizosaccharomyces pombe.

Martín-Cuadrado AB et al. J Cell Sci 2003 May 01;116(Pt 9):1689-98

PMID:16215171 - Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis.

Santos B et al. Eukaryot Cell 2005 Oct;4(10):1639-45

PMID:18466295 - The Schizosaccharomyces pombe endo-1,3-beta-glucanase Eng1 contains a novel carbohydrate binding module required for septum localization.

Martín-Cuadrado AB et al. Mol Microbiol 2008 Jul;69(1):188-200

PMID:19473263 - The involvement of the Schizosaccharomyces pombe sep9/spt8 gene in the regulation of septum cleavage.

Batta G et al. FEMS Yeast Res 2009 Aug;9(5):757-67

PMID:19542306 - {beta}-glucanase Eng2 is required for ascus wall endolysis after sporulation in the fission yeast Schizosaccharomyces pombe.

Encinar del Dedo J et al. Eukaryot Cell 2009 Aug;8(8):1278-86

PMID:18272786 - Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.

Ge W et al. Mol Biol Cell 2008 Apr;19(4):1680-92

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22508988 - Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.

St Amour CV et al. Mol Cell Biol 2012 Jul;32(13):2372-83

PMID:23093943 - Cytokinesis-based constraints on polarized cell growth in fission yeast.

Bohnert KA et al. PLoS Genet 2012;8(10):e1003004

PMID:16317047 - Ace2p contributes to fission yeast septin ring assembly by regulating mid2+ expression.

Petit CS et al. J Cell Sci 2005 Dec 15;118(Pt 24):5731-42

PMID:16415366 - A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.

Jin QW et al. Genetics 2006 Apr;172(4):2101-12

PMID:23457617 - Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast.

Eckler AM et al. PLoS One 2013;8(2):e56807

PMID:25825517 - A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.

Dudin O et al. J Cell Biol 2015 Mar 30;208(7):897-911

PMID:27548313 - Transcription factors mediate condensin recruitment and global chromosomal organization in fission yeast.

Kim KD et al. Nat Genet 2016 Oct;48(10):1242-52

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:19328067 - TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.

Viladevall L et al. Mol Cell 2009 Mar 27;33(6):738-51

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:31116668 - Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis.

Morris Z et al. Mol Biol Cell 2019 Jul 15;30(15):1791-1804

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:20852022 - Characterization of glycoside hydrolase family 5 proteins in Schizosaccharomyces pombe.

Dueñas-Santero E et al. Eukaryot Cell 2010 Nov;9(11):1650-60

PMID:25015293 - Septin ring assembly is regulated by Spt20, a structural subunit of the SAGA complex.

Lei B et al. J Cell Sci 2014 Sep 15;127(Pt 18):4024-36

PMID:32182184 - Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast.

Onwubiko UN et al. Small GTPases 2021 Jul;12(4):257-264

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:12845604 - Genome-wide identification of fungal GPI proteins.

De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96

PMID:17933563 - Characterization of the endo-beta-1,3-glucanase activity of S. cerevisiae Eng2 and other members of the GH81 family.

Martín-Cuadrado AB et al. Fungal Genet Biol 2008 Apr;45(4):542-53

PMID:23977061 - Regulation of cell wall synthesis by the clathrin light chain is essential for viability in Schizosaccharomyces pombe.

de León N et al. PLoS One 2013;8(8):e71510

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:33533152 - Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.

Sweta K et al. Mol Microbiol 2021 Jul;116(1):80-96

PMID:15689498 - Ace2p controls the expression of genes required for cell separation in Schizosaccharomyces pombe.

Alonso-Nuñez ML et al. Mol Biol Cell 2005 Apr;16(4):2003-17

PMID:34798057 - Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation.

Finet O et al. Mol Cell 2022 Jan 20;82(2):404-419.e9

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.

Morozumi Y et al. iScience 2024 Jan 19;27(1):108777

PMID:39660919 - Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation.

Innokentev A et al. mBio 2024 Dec 11;:e0299224

PMID:40402811 - Characterization of oncohistone H2B variants in Schizosaccharomyces pombe reveals a key role of H2B monoubiquitination deficiency in genomic instability by altering gene expression.

Lu G et al. FEMS Yeast Res 2025 May 22;

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.

Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279

PMID:25411334 - The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.

Wang N et al. Mol Biol Cell 2015 Jan 15;26(2):238-55

PMID:15194814 - Role of the alpha-glucanase Agn1p in fission-yeast cell separation.

Dekker N et al. Mol Biol Cell 2004 Aug;15(8):3903-14

PMID:33771877 - RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.

Rivosecchi J et al. Life Sci Alliance 2021 Jun;4(6)

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:27082518 - Roles of the TRAPP-II Complex and the Exocyst in Membrane Deposition during Fission Yeast Cytokinesis.

Wang N et al. PLoS Biol 2016 Apr;14(4):e1002437

PMID:7275933 - Isolation, properties, function, and regulation of endo-(1 leads to 3)-beta-glucanases in Schizosaccharomyces pombe.

Reichelt BY et al. J Bacteriol 1981 Sep;147(3):1085-94

PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.

Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8

PMID:29899453 - A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II.

Parua PK et al. Nature 2018 Jun;558(7710):460-464

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:34910579 - Involvement of Smi1 in cell wall integrity and glucan synthase Bgs4 localization during fission yeast cytokinesis.

Longo LVG et al. Mol Biol Cell 2022 Feb 01;33(2):ar17