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protein coding gene - sod1 (SPAC821.10c) - superoxide dismutase Sod1

Gene summary

Standard name
sod1
Systematic ID
SPAC821.10c
Product
superoxide dismutase Sod1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P28758
ORFeome ID
04/04C02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1002838..1003600 reverse strand

Annotation

Disease association

MONDO:0007103 - amyotrophic lateral sclerosis type 1

References:

MONDO:0020128 - motor neuron disorder

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MONDO:0005071 - nervous system disorder

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MONDO:0032828 - spastic tetraplegia and axial hypotonia, progressive

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GO biological process

GO:0045454 - cell redox homeostasis

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GO:0006878 - intracellular copper ion homeostasis

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GO:0006882 - intracellular zinc ion homeostasis

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GO:0019430 - removal of superoxide radicals

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GO cellular component

GO:0005829 - cytosol

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GO:0005758 - mitochondrial intermembrane space

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GO molecular function

GO:0005507 - copper ion binding

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GO:0004784 - superoxide dismutase activity

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Modification

MOD:00689 - disulfide crosslinked residues

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MOD:00595 - mannosylated residue

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MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:01149 - sumoylated lysine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0003862 - increased protein oxidation in stationary phase

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0000108 - sensitive to menadione

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Genotypes:

FYPO:0002692 - sensitive to paraquat

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Genotypes:

FYPO:0003116 - sensitive to plumbagin

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000020 - protein level unchanged

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000013 - RNA level unchanged

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

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Genotypes:

FYPO:0002753 - abolished cell population growth on sulfate sulfur source

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Genotypes:

FYPO:0003360 - abolished superoxide dismutase activity

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Genotypes:

FYPO:0003238 - decreased anaerobic cell population growth

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Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

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Genotypes:

FYPO:0000249 - decreased cell population growth on ammonia nitrogen source

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Genotypes:

FYPO:0001752 - decreased homocitrate synthase activity

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0001128 - decreased septation index

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0001755 - growth auxotrophic for lysine and cysteine

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Genotypes:

FYPO:0001754 - growth auxotrophic for lysine and methionine

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0001551 - increased protein level during cellular response to zinc ion starvation

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Genotypes:

FYPO:0003863 - increased protein oxidation

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Genotypes:

FYPO:0001890 - increased RNA level

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Genotypes:

FYPO:0004785 - increased RNA level during cellular response to menadione

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Genotypes:

FYPO:0000316 - inviable after spore germination

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001753 - normal anaerobic cell population growth

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Genotypes:

FYPO:0001437 - normal growth on antimycin A

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Genotypes:

FYPO:0002690 - normal growth on cumene hydroperoxide

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Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

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Genotypes:

FYPO:0002691 - normal growth on menadione

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Genotypes:

FYPO:0005884 - normal growth on myxothiazol

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Genotypes:

FYPO:0001691 - normal growth on paraquat

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Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0008287 - sensitive to 1-chloro-2,4-dinitrobenzene

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0007152 - sensitive to camphor

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Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

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Genotypes:

FYPO:0002689 - sensitive to cumene hydroperoxide

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Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000108 - sensitive to menadione

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Genotypes:

FYPO:0007929 - sensitive to phloxine B

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0000116 - sensitive to zinc

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00080Sod_CuSOD_Cu_Zn_domPFAM
cd00305Cu-Zn_Superoxide_DismutaseSOD_Cu_Zn_domCDD
PS00332SOD_CU_ZN_2SOD_Cu/Zn_BSPROSITE_PATTERNS
PS00087SOD_CU_ZN_1SOD_Cu/Zn_BSPROSITE_PATTERNS
PR00068CUZNDISMTASESOD_Cu_Zn_domPRINTS
G3DSA:2.60.40.200:FF:000001FUNFAM
SSF49329Cu,Zn superoxide dismutase-likeSOD-like_Cu/Zn_dom_sfSUPERFAMILY
G3DSA:2.60.40.200Superoxide dismutase, copper/zinc binding domainSOD-like_Cu/Zn_dom_sfGENE3D
PTHR10003SUPEROXIDE DISMUTASE CU-ZN -RELATEDSOD_Cu/Zn_/chaperonePANTHER

Orthologs

References / Literature

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:30931102 - Oxidative stress-mediated apoptotic cell death induced by camphor in sod1 -deficient Schizosaccharomyces pombe .
Agus HH et al. Toxicol Res (Camb) 2019 Mar 01;8(2):216-226
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:28572514 - Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination.
Plante S et al. J Biol Chem 2017 Jul 14;292(28):11896-11914
PMID:15645504 - Pro-oxidant action of phloxine B on fission yeast Schizosaccharomyces pombe.
Mutoh N et al. Yeast 2005 Jan 30;22(2):91-7
PMID:16428309 - Effects of four oxidants, menadione, 1-chloro-2,4-dinitrobenzene, hydrogen peroxide and cumene hydroperoxide, on fission yeast Schizosaccharmoyces pombe.
Mutoh N et al. J Biochem 2005 Dec;138(6):797-804
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:36174923 - Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Δppr10 cells with defective mitochondrial protein synthesis.
Hu Y et al. Int J Biochem Cell Biol 2022 Nov;152:106308
PMID:39761853 - Regulation of sod1 mRNA and protein abundance by zinc in fission yeast is dependent on the CCR4-NOT complex.
Weeks AT et al. J Biol Chem 2025 Jan 04;:108156
PMID:24569997 - Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.
Plante S et al. J Biol Chem 2014 Apr 04;289(14):10168-81
PMID:12073089 - Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe.
Mutoh N et al. Curr Genet 2002 May;41(2):82-8
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:17986764 - Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency.
Mutoh N et al. Biosci Biotechnol Biochem 2007 Nov;71(11):2841-4
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.
Bernal M et al. Proteomics 2014 Jun;14(11):1367-80
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:19682301 - A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.
Paul SK et al. FEBS J 2009 Sep;276(18):5076-93
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:12359231 - Regulation and the role of Cu,Zn-containing superoxide dismutase in cell cycle progression of Schizosaccharomyces pombe.
Lee J et al. Biochem Biophys Res Commun 2002 Oct 04;297(4):854-62
PMID:19266076 - Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.
Roux AE et al. PLoS Genet 2009 Mar;5(3):e1000408
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PB_REF:0000003 - Disease Association Curation
PMID:27005325 - Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions.
Pluskal T et al. Genes Cells 2016 Jun;21(6):530-42
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:17409354 - The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast.
Jara M et al. Mol Biol Cell 2007 Jun;18(6):2288-95
PMID:24997422 - The role of frataxin in fission yeast iron metabolism: implications for Friedreich's ataxia.
Wang Y et al. Biochim Biophys Acta 2014 Oct;1840(10):3022-33
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:18072251 - The effect of superoxide dismutase deficiency on zinc toxicity in Schizosaccharomyces pombe.
Tarhan C et al. J Basic Microbiol 2007 Dec;47(6):506-12
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36309474 - Resorcinol alleviates alpha-terpineol-induced cell death in Schizosaccharomyces pombe via increased activity of the antioxidant enzyme Sod2.
Agus HH et al. FEMS Yeast Res 2022 Nov 11;22(1)
PMID:26507459 - Mitochondrial superoxide dismutase deficiency accelerates chronological aging in the fission yeast Schizosaccharomyces pombe.
Ogata T et al. Cell Biol Int 2016 Jan;40(1):100-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:11350071 - Characterization of the manganese-containing superoxide dismutase and its gene regulation in stress response of Schizosaccharomyces pombe.
Jeong JH et al. Biochem Biophys Res Commun 2001 May 18;283(4):908-14
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:12243351 - Regulation of Schizosaccharomyces pombe gene encoding copper/zinc superoxide dismutase.
Lee YY et al. Mol Cells 2002 Aug 31;14(1):43-9
PMID:16299000 - Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe.
Kwon ES et al. J Biol Chem 2006 Jan 20;281(3):1345-51