protein coding gene - sod1 (SPAC821.10c) - cytosolic superoxide dismutase Sod1

Gene summary

Standard name

sod1

Systematic ID

SPAC821.10c

Product

cytosolic superoxide dismutase Sod1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P28758

ORFeome ID

04/04C02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1002838..1003600 reverse strand

Annotation

Protein features

Orthologs

• SOD1 (HGNC:11179) Homo sapiens
• sod1 (SJAG_00668) Schizosaccharomyces japonicus
• SOD1 (YJR104C) Saccharomyces cerevisiae

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:12073089 - Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe.

Mutoh N et al. Curr Genet 2002 May;41(2):82-8

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.

Bernal M et al. Proteomics 2014 Jun;14(11):1367-80

PMID:15645504 - Pro-oxidant action of phloxine B on fission yeast Schizosaccharomyces pombe.

Mutoh N et al. Yeast 2005 Jan 30;22(2):91-7

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:15107426 - The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways.

Laliberté J et al. J Biol Chem 2004 Jul 02;279(27):28744-55

PMID:24569997 - Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.

Plante S et al. J Biol Chem 2014 Apr 04;289(14):10168-81

PMID:16428309 - Effects of four oxidants, menadione, 1-chloro-2,4-dinitrobenzene, hydrogen peroxide and cumene hydroperoxide, on fission yeast Schizosaccharmoyces pombe.

Mutoh N et al. J Biochem 2005 Dec;138(6):797-804

PMID:17409354 - The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast.

Jara M et al. Mol Biol Cell 2007 Jun;18(6):2288-95

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:17986764 - Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency.

Mutoh N et al. Biosci Biotechnol Biochem 2007 Nov;71(11):2841-4

PMID:26507459 - Mitochondrial superoxide dismutase deficiency accelerates chronological aging in the fission yeast Schizosaccharomyces pombe.

Ogata T et al. Cell Biol Int 2016 Jan;40(1):100-6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PB_REF:0000003 - Disease Association Curation

PMID:36174923 - Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Δppr10 cells with defective mitochondrial protein synthesis.

Hu Y et al. Int J Biochem Cell Biol 2022 Nov;152:106308

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:19682301 - A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.

Paul SK et al. FEBS J 2009 Sep;276(18):5076-93

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:11350071 - Characterization of the manganese-containing superoxide dismutase and its gene regulation in stress response of Schizosaccharomyces pombe.

Jeong JH et al. Biochem Biophys Res Commun 2001 May 18;283(4):908-14

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:30931102 - Oxidative stress-mediated apoptotic cell death induced by camphor in sod1 -deficient Schizosaccharomyces pombe .

Agus HH et al. Toxicol Res (Camb) 2019 Mar 01;8(2):216-226

PMID:27005325 - Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions.

Pluskal T et al. Genes Cells 2016 Jun;21(6):530-42

PMID:18072251 - The effect of superoxide dismutase deficiency on zinc toxicity in Schizosaccharomyces pombe.

Tarhan C et al. J Basic Microbiol 2007 Dec;47(6):506-12

PMID:12243351 - Regulation of Schizosaccharomyces pombe gene encoding copper/zinc superoxide dismutase.

Lee YY et al. Mol Cells 2002 Aug 31;14(1):43-9

PMID:36309474 - Resorcinol alleviates alpha-terpineol-induced cell death in Schizosaccharomyces pombe via increased activity of the antioxidant enzyme Sod2.

Agus HH et al. FEMS Yeast Res 2022 Nov 11;22(1)

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:12359231 - Regulation and the role of Cu,Zn-containing superoxide dismutase in cell cycle progression of Schizosaccharomyces pombe.

Lee J et al. Biochem Biophys Res Commun 2002 Oct 04;297(4):854-62

PMID:16299000 - Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe.

Kwon ES et al. J Biol Chem 2006 Jan 20;281(3):1345-51

PMID:24997422 - The role of frataxin in fission yeast iron metabolism: implications for Friedreich's ataxia.

Wang Y et al. Biochim Biophys Acta 2014 Oct;1840(10):3022-33

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28572514 - Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination.

Plante S et al. J Biol Chem 2017 Jul 14;292(28):11896-11914

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:19266076 - Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.

Roux AE et al. PLoS Genet 2009 Mar;5(3):e1000408

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:39761853 - Regulation of sod1 mRNA and protein abundance by zinc in fission yeast is dependent on the CCR4-NOT complex.

Weeks AT et al. J Biol Chem 2025 Jan 04;:108156