protein coding gene - ppa1 (SPAC823.15) - serine/threonine protein phosphatase PP2A catalytic subunit Ppa1

Gene summary

Standard name

ppa1

Systematic ID

SPAC823.15

Product

serine/threonine protein phosphatase PP2A catalytic subunit Ppa1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P23635

ORFeome ID

13/13A05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2607796..2609360 forward strand

Annotation

Protein features

Orthologs

• PPP2CA (HGNC:9299) Homo sapiens
• PPP2CB (HGNC:9300) Homo sapiens
• SJAG_00600 Schizosaccharomyces japonicus
• PPH21 (YDL134C) Saccharomyces cerevisiae
• PPH22 (YDL188C) Saccharomyces cerevisiae

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:19371376 - Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Hanyu Y et al. Genes Cells 2009 May;14(5):539-54

PMID:16541025 - Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

Kitajima TS et al. Nature 2006 May 04;441(7089):46-52

PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Goyal A et al. Genetics 2012 Apr;190(4):1235-50

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:8389306 - Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

Kinoshita N et al. Genes Dev 1993 Jun;7(6):1059-71

PMID:16541024 - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Riedel CG et al. Nature 2006 May 04;441(7089):53-61

PMID:1756736 - The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

Warbrick E et al. EMBO J 1991 Dec;10(13):4291-9

PMID:22403715 - Regulation of fission yeast morphogenesis by PP2A activator pta2.

Bernal M et al. PLoS One 2012;7(3):e32823

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.

Bernal M et al. Proteomics 2014 Jun;14(11):1367-80

PMID:2170029 - Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle.

Kinoshita N et al. Cell 1990 Oct 19;63(2):405-15

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30

PMID:36006032 - Analysis of the potential role of fission yeast PP2A in spindle assembly checkpoint inactivation.

Deng DJ et al. FASEB J 2022 Sep;36(9):e22524

PMID:7983142 - A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning.

Yoshida T et al. J Cell Sci 1994 Jul;107 ( Pt 7):1725-35

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:26152587 - TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.

Laor D et al. mBio 2015 Jul 07;6(4):e00959

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:31833215 - Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.

Shetty M et al. Aging Cell 2020 Feb;19(2):e13068

GO_REF:0000051 - S. pombe keyword mapping

PMID:8387356 - Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosis.

Shimanuki M et al. Mol Biol Cell 1993 Mar;4(3):303-13

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016