PomBase home

protein coding gene - pam18 (SPAC824.06) - PAM complex DNAJ subunit Pam18/Tim14

Gene summary

Standard name
pam18
Systematic ID
SPAC824.06
Product
PAM complex DNAJ subunit Pam18/Tim14
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
tim14
UniProt ID
Q9UT37
ORFeome ID
05/05C01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1695016..1696484 forward strand

Annotation

Disease association

MONDO:0012435 - 3-methylglutaconic aciduria type 5

References:

GO biological process

GO:0030150 - protein import into mitochondrial matrix

References:

GO cellular component

GO:0005739 - mitochondrion

References:

GO:0001405 - PAM complex, Tim23 associated import motor

References:

GO molecular function

GO:0001671 - ATPase activator activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
cd06257DnaJDnaJ_domainCDD
PS50076DNAJ_2DnaJ_domainPROSITE_PROFILES
SM00271dnaj_3DnaJ_domainSMART
G3DSA:1.10.287.110:FF:000001FUNFAM
SSF46565Chaperone J-domainJ_dom_sfSUPERFAMILY
G3DSA:1.10.287.110DnaJ domainJ_dom_sfGENE3D
PTHR12763PANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6