PomBase home

protein coding gene - gda1 (SPAC824.08) - Golgi nucleoside-diphosphatase Gda1

Gene summary

Standard name
gda1
Systematic ID
SPAC824.08
Product
Golgi nucleoside-diphosphatase Gda1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
gdp1
UniProt ID
Q9UT35
ORFeome ID
34/34H12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1697871..1700162 forward strand

Annotation

Complementation

PBO:0001129 - functionally complements S. cerevisiae GDA1

References:

GO biological process

GO:0009134 - nucleoside diphosphate catabolic process

References:

GO:0006487 - protein N-linked glycosylation

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0005794 - Golgi apparatus

References:

GO:0000139 - Golgi membrane

References:

GO molecular function

GO:0004382 - GDP phosphatase activity

References:

GO:0017111 - ribonucleoside triphosphate phosphatase activity

References:

GO:0045134 - UDP phosphatase activity

References:

GO:0043262 - ADP phosphatase activity

References:

GO:0016887 - ATP hydrolysis activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001477 - decreased guanosine-diphosphatase activity

References:

Genotypes:

FYPO:0001478 - increased guanosine-diphosphatase activity

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0001142 - normal Man8GlcNAc level

References:

Genotypes:

FYPO:0001143 - normal Man9GlcNAc level

References:

Genotypes:

FYPO:0000579 - normal spore germination

References:

Genotypes:

FYPO:0000590 - normal sporulation

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0000067 - resistance to brefeldin A

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF01150GDA1_CD39GDA1_CD39_NTPasePFAM
cd24040ASKHA_NBD_GDA1CDD
PS01238GDA1_CD39_NTPASEGDA1_CD39_NTPasePROSITE_PATTERNS
G3DSA:3.30.420.40GENE3D
G3DSA:3.30.420.150Exopolyphosphatase. Domain 2GENE3D
PTHR11782ADENOSINE/GUANOSINE DIPHOSPHATASEGDA1_CD39_NTPasePANTHER

Orthologs

References / Literature

PMID:14612233 - Characterization of gdp1+ as encoding a GDPase in the fission yeast Schizosaccharomyces pombe.
Sánchez R et al. FEMS Microbiol Lett 2003 Nov 07;228(1):33-8
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:12686557 - Nucleoside diphosphatase and glycosyltransferase activities can localize to different subcellular compartments in Schizosaccharomyces pombe.
D'Alessio C et al. J Biol Chem 2003 Jun 20;278(25):22379-87
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663