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protein coding gene - yhb1 (SPAC869.02c) - nitric oxide dioxygenase Yhb1

Gene summary

Standard name
yhb1
Systematic ID
SPAC869.02c
Product
nitric oxide dioxygenase Yhb1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9URY5
ORFeome ID
22/22C04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5517951..5519950 forward strand

Annotation

GO biological process

GO:0070458 - cellular detoxification of nitrogen compound

References:

GO:0071500 - cellular response to nitrosative stress

References:

GO:0046210 - nitric oxide catabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

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GO:0005634 - nucleus

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GO molecular function

GO:0071949 - FAD binding

References:

GO:0020037 - heme binding

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GO:0008941 - nitric oxide dioxygenase NAD(P)H activity

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GO:0019825 - oxygen binding

References:

Modification

MOD:00046 - O-phospho-L-serine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0006409 - increased cellular nitric oxide level during stationary phase

References:

Genotypes:

FYPO:0003114 - increased cellular nitric oxide level during vegetative growth

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Genotypes:

FYPO:0007615 - increased transcription from STREP promoter during cellular response to nitric oxide

References:

Genotypes:

FYPO:0006407 - sensitive to nitrosative stress

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000020 - protein level unchanged

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PomGeneEx:0000021 - protein present

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0007615 - increased transcription from STREP promoter during cellular response to nitric oxide

References:

Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0009060 - resistance to wortmannin

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF00042GlobinGlobinPFAM
PF00970FAD_binding_6Cbr1-like_FAD-bd_domPFAM
PF00175NAD_binding_1OxRdtase_FAD/NAD-bdPFAM
cd19754FHb_fungal-globinCDD
cd06184flavohem_like_fad_nad_bindingCDD
PS01033GLOBINGlobinPROSITE_PROFILES
PS51384FAD_FRFAD-bd_FR_typePROSITE_PROFILES
G3DSA:1.10.490.10:FF:000003FUNFAM
SSF46458Globin-likeGlobin-like_sfSUPERFAMILY
SSF63380Riboflavin synthase domain-likeRiboflavin_synthase-like_b-brlSUPERFAMILY
SSF52343Ferredoxin reductase-like, C-terminal NADP-linked domainFNR_nucleotide-bdSUPERFAMILY
G3DSA:1.10.490.10GlobinsGlobin/ProtoGENE3D
G3DSA:2.40.30.10Translation factorsGENE3D
G3DSA:3.40.50.80FNR_nucleotide-bdGENE3D
PTHR43396FLAVOHEMOPROTEINPANTHER

Orthologs

References / Literature

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33400299 - Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.
Jiang G et al. Mol Microbiol 2021 Jun;115(6):1323-1338
PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.
Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22235339 - The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.
Lando D et al. PLoS One 2012;7(1):e29765
GO_REF:0000002 - Comments
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26645666 - Nitric oxide signaling and its role in oxidative stress response in Schizosaccharomyces pombe.
Astuti RI et al. Nitric Oxide 2016 Jan 30;52:29-40
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:31657618 - A Genome-Wide Screen for Wortmannin-Resistant Mutants in Schizosaccharomyces pombe: The Phosphorylation-Impaired Mutants Are Resistant to Signaling Defect.
Yılmazer M et al. DNA Cell Biol 2019 Dec;38(12):1427-1436
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83