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protein coding gene - mel1 (SPAC869.07c) - alpha-galactosidase, melibiase

Gene summary

Standard name
mel1
Systematic ID
SPAC869.07c
Product
alpha-galactosidase, melibiase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9URZ0
ORFeome ID
44/44C02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5499782..5501236 forward strand

Annotation

Disease association

MONDO:0017779 - alpha-N-acetylgalactosaminidase deficiency

References:

MONDO:0012221 - alpha-N-acetylgalactosaminidase deficiency type 1

References:

MONDO:0012222 - alpha-N-acetylgalactosaminidase deficiency type 2

References:

MONDO:0010526 - Fabry disease

References:

Experimental tools

PBO:0002996 - gene reporter system

References:

GO biological process

GO:0016052 - carbohydrate catabolic process

References:

GO:0005995 - melibiose catabolic process

References:

GO cellular component

GO:0005788 - endoplasmic reticulum lumen

References:

GO:0005576 - extracellular region

References:

GO molecular function

GO:0004557 - alpha-galactosidase activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00006 - N-glycosylated residue

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004564 - increased alpha-galactosidase activity

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF16499Melibiase_2Glyco_hydro_27Pfam
PF17801Melibiase_CMelibiase_CPfam
cd14792GH27Glyco_hydro_27CDD
PS00512ALPHA_GALACTOSIDASEGlyco_hydro_27/36_CSPROSITE patterns
PR00740GLHYDRLASE27Glyco_hydro_27PRINTS
PR00748MELIBIASEGlyco_hydro_melibiasePRINTS
G3DSA:3.20.20.70:FF:000202CATH-FunFam
G3DSA:2.60.40.1180Glyco_hydro_bCATH-Gene3D
G3DSA:3.20.20.70Aldolase_TIMCATH-Gene3D
SSF51011SUPERFAMILY
SSF51445GH_hydrolase_sfSUPERFAMILY
PTHR11452Glyco_hydro_27PANTHER
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.
Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837
PMID:42030144 - Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast.
Du XM et al. Proc Natl Acad Sci U S A 2026 Apr 28;123(17):e2532532123
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26804021 - Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
Tashiro S et al. Nat Commun 2016 Jan 25;7:10393
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Su Y et al. FEBS J 2017 Jan;284(2):324-337
PMID:15580593 - Development of a semi-quantitative plate-based alpha-galactosidase gene reporter for Schizosaccharomyces pombe and its use to isolate a constitutively active Mam2.
Goddard A et al. Yeast 2005 Jan 15;22(1):31-41
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:40520116 - Histone deacetylation as a landmark for Sgo2 relocation from centromeres to subtelomeres during interphase.
Osaki M et al. iScience 2025 Jun 20;28(6):112717
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000003 - Disease Association Curation