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protein coding gene - nup155 (SPAC890.06) - nucleoporin, WD repeat Nup155

Gene summary

Standard name
nup155
Systematic ID
SPAC890.06
Product
nucleoporin, WD repeat Nup155
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
nup157, nup170
UniProt ID
Q9URX8
ORFeome ID
30/30F01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5011688..5016066 forward strand

Annotation

Disease association

MONDO:0014340 - atrial fibrillation, familial, 15

References:

MONDO:0005267 - heart disorder

References:

GO biological process

GO:0006606 - protein import into nucleus

References:

GO:0036228 - protein localization to nuclear inner membrane

References:

GO:0000054 - ribosomal subunit export from nucleus

References:

GO:0006405 - RNA export from nucleus

References:

GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005635 - nuclear envelope

References:

GO:0005643 - nuclear pore

References:

GO:0044611 - nuclear pore inner ring

References:

GO molecular function

GO:0017056 - structural constituent of nuclear pore

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0001908 - increased pre-mRNA level

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03177Nucleoporin_CNucleoporin_Nup133/Nup155_CPfam
PF08801Nucleoporin_NNucleoporin_Nup133/Nup155_NPfam
G3DSA:1.20.120.1880:FF:000004CATH-FunFam
G3DSA:1.25.40.440:FF:000001CATH-FunFam
G3DSA:1.20.120.1880Nucleoporin_Nup155_C_3CATH-Gene3D
G3DSA:1.20.58.1780CATH-Gene3D
G3DSA:1.25.40.440Nucleoporin_Nup155_C_2CATH-Gene3D
G3DSA:1.25.40.450Nucleoporin_Nup155_C_1CATH-Gene3D
SSF101898SUPERFAMILY
PTHR10350Nucleoporin_Nup155PANTHER

Orthologs

References / Literature

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PB_REF:0000003 - Disease Association Curation
PMID:24637836 - Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.
Asakawa H et al. Nucleus 2014;5(2):149-62
PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:34010011 - Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state.
Borah S et al. Mol Biol Cell 2021 Jul 15;32(15):1359-1373
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:27172183 - Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.
Larson A et al. G3 (Bethesda) 2016 Jun 01;6(6):1513-23
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:39727334 - Interaction mapping between nucleoporins in the fission yeast Schizosaccharomyces pombe using mass-spectrometry.
Asakawa H et al. J Biochem 2024 Dec 27;
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8