protein coding gene - cgs1 (SPAC8C9.03) - cAMP-dependent protein kinase regulatory subunit Cgs1

Gene summary

Standard name

cgs1

Systematic ID

SPAC8C9.03

Product

cAMP-dependent protein kinase regulatory subunit Cgs1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

rak1

UniProt ID

P36600

ORFeome ID

24/24D06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3643029..3645636 forward strand

Annotation

Protein features

Orthologs

• PRKAR2A (HGNC:9391) Homo sapiens
• PRKAR2B (HGNC:9392) Homo sapiens
• cgs1 (SJAG_01245) Schizosaccharomyces japonicus
• BCY1 (YIL033C) Saccharomyces cerevisiae

References / Literature

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:18621924 - Regulation of the subcellular localization of cyclic AMP-dependent protein kinase in response to physiological stresses and sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Matsuo Y et al. Eukaryot Cell 2008 Sep;7(9):1450-9

PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.

Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697

PMID:21118717 - Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases.

Demirbas D et al. Cell Signal 2011 Mar;23(3):594-601

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:31562247 - Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast.

Zheng F et al. J Biol Chem 2019 Nov 22;294(47):17725-17734

PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.

Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:35171902 - The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.

Bao K et al. PLoS Genet 2022 Feb;18(2):e1010049

PMID:7862141 - The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.

Wu SY et al. Mol Cell Biol 1995 Mar;15(3):1479-88

PMID:16550352 - A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.

Nakashima A et al. Curr Genet 2006 Jun;49(6):403-13

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:29316864 - Overexpression of the transcription factor Rst2 in Schizosaccharomyces pombe indicates growth defect, mitotic defects, and microtubule disorder.

Takenaka K et al. Biosci Biotechnol Biochem 2018 Feb;82(2):247-257

PMID:18808426 - Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.

Miki R et al. FEBS J 2008 Nov;275(21):5309-24

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:10835385 - Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

Mach KE et al. Genetics 2000 Jun;155(2):611-22

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:8918880 - 20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway.

Yamashita YM et al. Nature 1996 Nov 21;384(6606):276-9

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:38598031 - Pps1, phosphatidylserine synthase, regulates the salt stress response in Schizosaccharomyces pombe.

Naozuka G et al. Mol Genet Genomics 2024 Apr 10;299(1):43

PMID:20634885 - TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.

Valbuena N et al. PLoS One 2010 Jul 09;5(7):e11514

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:21879336 - Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast.

Gupta DR et al. Curr Genet 2011 Oct;57(5):353-65

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .

Guydosh NR et al. Elife 2017 Sep 25;6

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:1849107 - Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Hoffman CS et al. Genes Dev 1991 Apr;5(4):561-71

PMID:1863602 - Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe.

Kawamukai M et al. Cell Regul 1991 Feb;2(2):155-64

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:12664134 - Inactivation of Ran1/Pat1 kinase bypasses the requirement for high-level expression of mei2 during fission yeast meiosis.

Peng Z et al. Curr Genet 2003 Jun;43(3):178-85

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:11872168 - Genes for a nuclease and a protease are involved in the drastic decrease in cellular RNA amount in fission yeast cells during nitrogen starvation.

Nakashima A et al. J Biochem 2002 Mar;131(3):391-8

PMID:11739717 - Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast.

Higuchi T et al. Mol Cell Biol 2002 Jan;22(1):1-11

PMID:15611161 - In vivo activation of protein kinase A in Schizosaccharomyces pombe requires threonine phosphorylation at its activation loop and is dependent on PDK1.

Tang Y et al. Genetics 2004 Dec;168(4):1843-53

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:20453258 - Living on the edge: stress and activation of stress responses promote lifespan extension.

Zuin A et al. Aging (Albany NY) 2010 Apr;2(4):231-7

PMID:9372444 - A zinc finger protein required for stationary phase viability in fission yeast.

Hao Z et al. J Cell Sci 1997 Oct;110 ( Pt 20):2557-66

PMID:10982411 - A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development.

Kunitomo H et al. Mol Biol Cell 2000 Sep;11(9):3205-17

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:8144551 - Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe.

Maeda T et al. J Biol Chem 1994 Apr 01;269(13):9632-7

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:10388805 - Regulation of mRNA export by nutritional status in fission yeast.

Whalen WA et al. Genetics 1999 Jul;152(3):827-38

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:10526233 - Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses.

Yamashita YM et al. Genes Cells 1999 Aug;4(8):445-63

PMID:11453251 - Factors involved in the regulation of the Schizosaccharomyces pombe malic enzyme gene.

Groenewald M et al. Curr Genet 2001 Jun;39(4):222-30

PMID:36358992 - Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription.

Asada R et al. Biomolecules 2022 Nov 05;12(11)

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:8557039 - Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase.

Takeda T et al. EMBO J 1995 Dec 15;14(24):6193-208

PMID:30973898 - Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant.

Tanabe T et al. PLoS One 2019;14(4):e0214803

PMID:1657594 - Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis.

DeVoti J et al. EMBO J 1991 Dec;10(12):3759-68

PMID:21869531 - Complex formation, phosphorylation, and localization of protein kinase A of Schizosaccharomyces pombe upon glucose starvation.

Gupta DR et al. Biosci Biotechnol Biochem 2011;75(8):1456-65

PMID:10805744 - Cpc2, a fission yeast homologue of mammalian RACK1 protein, interacts with Ran1 (Pat1) kinase To regulate cell cycle progression and meiotic development.

McLeod M et al. Mol Cell Biol 2000 Jun;20(11):4016-27

PMID:27756188 - cAMP-dependent protein kinase involves calcium tolerance through the regulation of Prz1 in Schizosaccharomyces pombe.

Matsuo Y et al. Biosci Biotechnol Biochem 2017 Feb;81(2):231-241

PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.

Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915

PMID:33400299 - Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.

Jiang G et al. Mol Microbiol 2021 Jun;115(6):1323-1338

PMID:8832415 - The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

Stettler S et al. J Cell Sci 1996 Jul;109 ( Pt 7):1927-35

PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.

Nakashima A et al. J Cell Sci 2010 Mar 01;123(Pt 5):777-86

PMID:15189983 - Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

Stiefel J et al. Eukaryot Cell 2004 Jun;3(3):610-9

PMID:11238405 - Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Janoo RT et al. Genetics 2001 Mar;157(3):1205-15

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:36112198 - Synergistic roles of the phospholipase B homolog Plb1 and the cAMP-dependent protein kinase Pka1 in the hypertonic stress response of Schizosaccharomyces pombe.

Matsuo Y et al. Curr Genet 2022 Dec;68(5-6):661-674

PMID:9135083 - Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation.

Kanoh J et al. Genes Cells 1996 Apr;1(4):391-408

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:32441227 - Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe .

Tanabe T et al. Biosci Biotechnol Biochem 2020 Aug;84(8):1667-1680

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:12715160 - The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Yang P et al. Mol Genet Genomics 2003 Apr;269(1):116-25

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29