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protein coding gene - fra2 (SPAC8C9.11) - iron-sensor Fra2

Gene summary

Standard name
fra2
Systematic ID
SPAC8C9.11
Product
iron-sensor Fra2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14280
ORFeome ID
01/01G02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3659089..3659824 forward strand

Annotation

GO biological process

GO:0010106 - cellular response to iron ion starvation

References:

GO:0006879 - intracellular iron ion homeostasis

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0051537 - 2 iron, 2 sulfur cluster binding

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GO:0005515 - protein binding

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GO:0140311 - protein sequestering activity

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GO:0003713 - transcription coactivator activity

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Modification

MOD:00739 - iron-sulfur cluster containing modification

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Multi-locus phenotype

FYPO:0002014 - increased RNA level during cellular response to iron ion starvation

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

Qualitative gene expression

PomGeneEx:0000013 - RNA level unchanged

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0005487 - decreased iron-sulfur cluster binding

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Genotypes:

FYPO:0005654 - decreased level of iron assimilation gene mRNA during vegetative growth

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Genotypes:

FYPO:0000826 - decreased RNA level

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Genotypes:

FYPO:0002042 - decreased RNA level during cellular response to iron ion starvation

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Genotypes:

FYPO:0009074 - increased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0009030 - resistance to amitrole

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000073 - resistance to caffeine

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

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Genotypes:

FYPO:0006930 - sensitive to butylated hydroxyanisole

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0002015 - sensitive to iron ion starvation

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF01722BolABolAPfam
G3DSA:3.30.300.90:FF:000006CATH-FunFam
G3DSA:3.30.300.90BolA-like_sfCATH-Gene3D
SSF82657BolA-like_sfSUPERFAMILY
PTHR12735BOL2PANTHER
PIRSF003113BolABolAPIRSF

Orthologs

References / Literature

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25806539 - A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.
Encinar del Dedo J et al. PLoS Genet 2015 Mar;11(3):e1005106
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37923140 - Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal.
Hati D et al. J Biol Chem 2023 Nov 03;299(12):105419
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24897379 - Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation.
Jacques JF et al. PLoS One 2014;9(6):e98959
PMID:30393157 - Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.
Shang J et al. Fungal Genet Biol 2019 Jan;122:11-20