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protein coding gene - prr1 (SPAC8C9.14) - stress-responsive DNA-binding transcription factor Prr1

Gene summary

Standard name
prr1
Systematic ID
SPAC8C9.14
Product
stress-responsive DNA-binding transcription factor Prr1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14283
ORFeome ID
38/38H04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3665932..3669087 forward strand

Annotation

Comment

PBO:0000206 - deletion mutant expression profiling

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GO biological process

GO:0031139 - positive regulation of conjugation with cellular fusion

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GO:0045944 - positive regulation of transcription by RNA polymerase II

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GO:0006357 - regulation of transcription by RNA polymerase II

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GO cellular component

GO:0000785 - chromatin

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GO:0005634 - nucleus

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GO:0090575 - RNA polymerase II transcription regulator complex

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GO molecular function

GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

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GO:0005515 - protein binding

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GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

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Modification

MOD:00042 - L-aspartic 4-phosphoric anhydride

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MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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MOD:01149 - sumoylated lysine

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Multi-locus phenotype

FYPO:0001117 - decreased RNA level during vegetative growth

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0005163 - increased RNA level during cellular response to heat

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0001246 - normal RNA level during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

Qualitative gene expression

PomGeneEx:0000026 - ribosomal density increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0000214 - abnormal mitotic chromosome condensation

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Genotypes:

FYPO:0000711 - decreased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

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Genotypes:

FYPO:0000046 - decreased cell population growth

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0001116 - decreased RNA level during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0002304 - decreased RNA level during cellular response to salt stress

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Genotypes:

FYPO:0001152 - decreased RNA level during nitrogen starvation

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Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

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Genotypes:

FYPO:0004142 - decreased RNA polymerase II proximal promoter sequence-specific DNA binding

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Genotypes:

FYPO:0001043 - increased mating efficiency

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Genotypes:

FYPO:0004571 - increased RNA level during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0002020 - increased RNA level during nitrogen starvation

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Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

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Genotypes:

FYPO:0001419 - normal cell population growth rate

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

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Genotypes:

FYPO:0001237 - normal growth on cadmium

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

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Genotypes:

FYPO:0001239 - normal growth on tert-butyl hydroperoxide

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Genotypes:

FYPO:0000838 - normal protein localization to nucleus during vegetative growth

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Genotypes:

FYPO:0002013 - normal protein oxidation during vegetative growth

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Genotypes:

FYPO:0001281 - normal protein phosphorylation during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0001246 - normal RNA level during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0001486 - normal RNA level during cellular response to salt stress

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Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

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Genotypes:

FYPO:0001996 - RNA absent from cell during nitrogen starvation

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Genotypes:

FYPO:0008287 - sensitive to 1-chloro-2,4-dinitrobenzene

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0002689 - sensitive to cumene hydroperoxide

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000108 - sensitive to menadione

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000280 - sterile

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00072Response_regSig_transdc_resp-reg_receiverPfam
PF00447HSF_DNA-bindHSF_DNA-bdPfam
cd17546REC_hyHK_CKI1_RcsC-likeCDD
PS00434HSF_DOMAINHSF_DNA-bdPROSITE patterns
PS50110RESPONSE_REGULATORYSig_transdc_resp-reg_receiverPROSITE profiles
SM00415HSFHSF_DNA-bdSMART
SM00448RECSig_transdc_resp-reg_receiverSMART
PR00056HSFDOMAINHSF_DNA-bdPRINTS
G3DSA:1.10.10.10:FF:000027CATH-FunFam
G3DSA:1.10.10.10WH-like_DNA-bd_sfCATH-Gene3D
G3DSA:3.40.50.2300CATH-Gene3D
SSF46785WH_DNA-bd_sfSUPERFAMILY
SSF52172CheY-like_sfSUPERFAMILY
PTHR10015PANTHER
PIRSF002595RR_SKN7SKN7PIRSF
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.
Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:20919928 - Two-component mediated peroxide sensing and signal transduction in fission yeast.
Quinn J et al. Antioxid Redox Signal 2011 Jul 01;15(1):153-65
PMID:10749922 - Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase.
Nguyen AN et al. Mol Biol Cell 2000 Apr;11(4):1169-81
PMID:12723602 - Characterization of the Prr1 response regulator with special reference to sexual development in Schizosaccharomyces pombe.
Nakamichi N et al. Biosci Biotechnol Biochem 2003 Mar;67(3):547-55
PMID:14633985 - RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress.
Rodríguez-Gabriel MA et al. EMBO J 2003 Dec 01;22(23):6256-66
PMID:22212525 - Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.
Ohtsuka H et al. Genes Cells 2012 Jan;17(1):39-52
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.
Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:11129048 - The Prr1 response regulator is essential for transcription of ste11+ and for sexual development in fission yeast.
Ohmiya R et al. Mol Gen Genet 2000 Nov;264(4):441-51
PMID:18003976 - Multiple pathways differentially regulate global oxidative stress responses in fission yeast.
Chen D et al. Mol Biol Cell 2008 Jan;19(1):308-17
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.
Nie M et al. Sci Rep 2015 Sep 25;5:14389
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16428309 - Effects of four oxidants, menadione, 1-chloro-2,4-dinitrobenzene, hydrogen peroxide and cumene hydroperoxide, on fission yeast Schizosaccharmoyces pombe.
Mutoh N et al. J Biochem 2005 Dec;138(6):797-804
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:17559414 - Functional characterization of the phosphorelay protein Mpr1p from Schizosaccharomyces pombe.
Tan H et al. FEMS Yeast Res 2007 Sep;7(6):912-21
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:12221110 - Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.
Greenall A et al. Mol Biol Cell 2002 Sep;13(9):2977-89
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:12073089 - Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe.
Mutoh N et al. Curr Genet 2002 May;41(2):82-8
PMID:10348908 - A fission yeast gene (prr1(+)) that encodes a response regulator implicated in oxidative stress response.
Ohmiya R et al. J Biochem 1999 Jun;125(6):1061-6
PMID:11179424 - Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.
Buck V et al. Mol Biol Cell 2001 Feb;12(2):407-19
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:12596864 - His-to-Asp phosphorelay circuitry for regulation of sexual development in Schizosaccharomyces pombe.
Nakamichi N et al. Biosci Biotechnol Biochem 2002 Dec;66(12):2663-72
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:12784644 - Salt stress induces the expression of Schizosaccharomyces pombe och1+, which encodes an initiation-specific alpha-1,6-mannosyltransferase for N-linked outer chain synthesis of cell wall mannoproteins.
Yamamoto K et al. Biosci Biotechnol Biochem 2003 Apr;67(4):927-9
PMID:22344694 - The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.
Calvo IA et al. Nucleic Acids Res 2012 Jun;40(11):4816-24