protein coding gene - inv2 (SPAC8E11.01c) - invertase, beta-fructofuranosidase Inv2

Gene summary

Standard name: inv2
Systematic ID: SPAC8E11.01c
Product: invertase, beta-fructofuranosidase Inv2
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPAC959.01, suc2
UniProt ID: O42878
ORFeome ID: 24/24G07
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 3385939..3388219 forward strand

Annotation

GO biological process

GO:0005987 - sucrose catabolic process

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0004575 - sucrose alpha-glucosidase activity

References:

GO_REF:0000033

Modification

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

PMID:29259000

Genotypes:

inv2delta/inv2delta

FYPO:0000470 - decreased mating type switching

References:

PMID:29852001

Genotypes:

inv2delta

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0009096 - increased cell population growth on xylose carbon source

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0001309 - increased viability in stationary phase

References:

PMID:35820914

Genotypes:

inv2delta

FYPO:0000764 - resistance to cycloheximide

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0009038 - resistance to egtazic acid

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0005193 - resistance to torin1

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0000785 - sensitive to formamide

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0000087 - sensitive to hydrogen peroxide

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0001719 - sensitive to lithium

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0003656 - sensitive to vanadate

References:

PMID:37787768

Genotypes:

inv2delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

inv2delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

inv2delta

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

ID	Name	InterPro name	DB name
PF08244	Glyco_hydro_32C	Glyco_hydro_32_C	PFAM
PF00251	Glyco_hydro_32N	Glyco_hydro_32_N	PFAM
cd18622	GH32_Inu-like		CDD
PS00609	GLYCOSYL_HYDROL_F32	Glyco_hydro_32_AS	PROSITE_PATTERNS
SM00640	glyco_32	Glyco_hydro_32	SMART
G3DSA:2.115.10.20:FF:000002			FUNFAM
SSF75005	Arabinanase/levansucrase/invertase	Glyco_hydro_beta-prop_sf	SUPERFAMILY
SSF49899	Concanavalin A-like lectins/glucanases	ConA-like_dom_sf	SUPERFAMILY
G3DSA:2.115.10.20	Glycosyl hydrolase domain; family 43	Glyco_hydro_beta-prop_sf	GENE3D
G3DSA:2.60.120.560			GENE3D
PTHR42800	EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)		PANTHER

Orthologs

SUC2 (YIL162W) Saccharomyces cerevisiae

References / Literature

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.: Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.: Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.: Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12