protein coding gene - dmc1 (SPAC8E11.03c) - RecA family ATPase Dmc1

Gene summary

Standard name

dmc1

Systematic ID

SPAC8E11.03c

Product

RecA family ATPase Dmc1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

dmp1

UniProt ID

O42634

ORFeome ID

16/16E09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3382264..3383404 forward strand

Annotation

Protein features

Orthologs

• DMC1 (HGNC:2927) Homo sapiens
• dmc1 (SJAG_02267) Schizosaccharomyces japonicus
• DMC1 (YER179W) Saccharomyces cerevisiae

References / Literature

PMID:12032093 - The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast.

Shimada M et al. EMBO J 2002 Jun 03;21(11):2807-18

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:32414915 - Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms.

Tsubouchi H et al. Proc Natl Acad Sci U S A 2020 Jun 02;117(22):12062-12070

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:15899844 - Fission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filaments.

Sauvageau S et al. Mol Cell Biol 2005 Jun;25(11):4377-87

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:19037101 - Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Willis N et al. Mol Biol Cell 2009 Feb;20(3):819-33

PMID:20655467 - Crossover invariance determined by partner choice for meiotic DNA break repair.

Hyppa RW et al. Cell 2010 Jul 23;142(2):243-55

PMID:18566005 - Structural and functional analyses of the DMC1-M200V polymorphism found in the human population.

Hikiba J et al. Nucleic Acids Res 2008 Jul;36(12):4181-90

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:15238514 - Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts.

Young JA et al. Genetics 2004 Jun;167(2):593-605

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:34208949 - Mapping and Analysis of Swi5 and Sfr1 Phosphorylation Sites.

Sevcovicova A et al. Genes (Basel) 2021 Jun 30;12(7)

PMID:39340300 - The Swi5-Sfr1 complex regulates Dmc1- and Rad51-driven DNA strand exchange proceeding through two distinct three-stranded intermediates by different mechanisms.

Ito K et al. Nucleic Acids Res 2024 Sep 28;

PMID:16921379 - The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro.

Haruta N et al. Nat Struct Mol Biol 2006 Sep;13(9):823-30

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:14551247 - Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks.

Catlett MG et al. Mol Biol Cell 2003 Nov;14(11):4707-20

PMID:27304859 - Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.

Polakova S et al. PLoS Genet 2016 Jun;12(6):e1006102

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000002 - Comments

PMID:15210864 - Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates with Meu13 and is required for meiotic recombination.

Saito TT et al. Nucleic Acids Res 2004;32(11):3325-39

GO_REF:0000051 - S. pombe keyword mapping

PMID:25414342 - Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination.

Lorenz A et al. Nucleic Acids Res 2014 Dec 16;42(22):13723-35

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:22855558 - Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex.

Wehrkamp-Richter S et al. Nucleic Acids Res 2012 Oct;40(19):9633-46

PMID:14668362 - Five RecA-like proteins of Schizosaccharomyces pombe are involved in meiotic recombination.

Grishchuk AL et al. Genetics 2003 Nov;165(3):1031-43

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:24186976 - Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.

Murayama Y et al. Genes Dev 2013 Nov 01;27(21):2299-304

PMID:19028606 - Functional interactions of meiotic recombination factors Rdh54 and Dmc1.

Chi P et al. DNA Repair (Amst) 2009 Feb 01;8(2):279-84

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:10908327 - Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination.

Fukushima K et al. Nucleic Acids Res 2000 Jul 15;28(14):2709-16