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protein coding gene - brr6 (SPAC8F11.06) - nuclear envelope protein Brr6/Brl1

Gene summary

Standard name
brr6
Systematic ID
SPAC8F11.06
Product
nuclear envelope protein Brr6/Brl1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
brl1
UniProt ID
Q9UT30
ORFeome ID
12/12B09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2862416..2863845 forward strand

Annotation

Complementation

PBO:0001777 - functionally complemented by P. carnii Brl1

References:

Disease association

MONDO:0012363 - retinitis pigmentosa 32

References:

GO biological process

GO:0140480 - mitotic spindle pole body insertion into the nuclear envelope

References:

GO:0006998 - nuclear envelope organization

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GO:0051292 - nuclear pore complex assembly

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GO:0090307 - mitotic spindle assembly

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GO cellular component

GO:0044732 - mitotic spindle pole body

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GO:0005635 - nuclear envelope

References:

GO:0031965 - nuclear membrane

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GO:1990578 - perinuclear endoplasmic reticulum membrane

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GO:0005643 - nuclear pore

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0000135 - abnormal plasma membrane sterol distribution

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Genotypes:

FYPO:0007426 - abolished new mitotic spindle pole body insertion into nuclear envelope

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Genotypes:

FYPO:0001122 - elongated vegetative cell

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Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002018 - mitotic spindle absent from cell

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Genotypes:

FYPO:0000060 - mononucleate vegetative cell

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Genotypes:

FYPO:0000276 - monopolar mitotic spindle

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Genotypes:

FYPO:0005380 - normal mitotic spindle pole body duplication

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Genotypes:

FYPO:0003750 - normal nuclear pore density

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Genotypes:

FYPO:0000771 - normal nuclear pore localization

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Genotypes:

FYPO:0000772 - perforated nuclear envelope

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Genotypes:

FYPO:0002237 - sensitive to cerulenin

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF10104Brr6_like_C_CBrl1/Brr6_domPfam
SM01042Brr6_like_C_CBrl1/Brr6_domSMART
PTHR28136Brl1/Brr6PANTHER
Transmembrane alpha helixDeepTMHMM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMobiDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:38895340 - CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.
Mathiowetz AJ et al. bioRxiv 2024 Jun 08;
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:34133218 - Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
Bestul AJ et al. Mol Biol Cell 2021 Aug 01;32(16):1487-1500
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:22042620 - Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.
Tamm T et al. J Cell Biol 2011 Oct 31;195(3):467-84
PMID:15882446 - Brl1p -- a novel nuclear envelope protein required for nuclear transport.
Saitoh YH et al. Traffic 2005 Jun;6(6):502-17
PMID:17993570 - Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis.
Lo Presti L et al. Eukaryot Cell 2007 Dec;6(12):2448-52
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.
Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477
PMID:42425079 - A conserved mechanism of membrane fusion in nuclear pore complex assembly.
Fischer JS et al. Mol Cell 2026 Jul 09;
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72