protein coding gene - fml1 (SPAC9.05) - ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1

Gene summary

Standard name

fml1

Systematic ID

SPAC9.05

Product

ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

mfh1

UniProt ID

Q9UT23

ORFeome ID

38/38F02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1470834..1476275 forward strand

Annotation

Protein features

Orthologs

• FANCM (HGNC:23168) Homo sapiens
• fml1 (SJAG_02294) Schizosaccharomyces japonicus
• MPH1 (YIR002C) Saccharomyces cerevisiae

References / Literature

PMID:41873186 - Homologous recombination mutants cause differing lethality between h- and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin.

Kolesar P et al. FEBS J 2026 Mar 23;

PMID:40594858 - Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions.

Bakosova A et al. Sci Rep 2025 Jul 01;15(1):21895

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:25414342 - Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination.

Lorenz A et al. Nucleic Acids Res 2014 Dec 16;42(22):13723-35

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:31712578 - DNA sequence differences are determinants of meiotic recombination outcome.

Brown SD et al. Sci Rep 2019 Nov 11;9(1):16446

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.

Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.

Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605

GO_REF:0000002 - Comments

PMID:22844101 - The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair.

Nandi S et al. Nucleic Acids Res 2012 Oct;40(19):9584-95

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:30667359 - Factors affecting template switch recombination associated with restarted DNA replication.

Jalan M et al. Elife 2019 Jan 22;8

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:20347428 - A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.

Yan Z et al. Mol Cell 2010 Mar 26;37(6):865-78

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71

PMID:28586299 - Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication.

Morrow CA et al. Elife 2017 Jun 06;6

PMID:18851838 - The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.

Sun W et al. Mol Cell 2008 Oct 10;32(1):118-28

PMID:28977643 - Regulation of mitotic recombination between DNA repeats in centromeres.

Zafar F et al. Nucleic Acids Res 2017 Nov 02;45(19):11222-11235

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.

Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:32269268 - Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin.

Dong W et al. Sci Rep 2020 Apr 08;10(1):6055

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22723423 - The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.

Lorenz A et al. Science 2012 Jun 22;336(6088):1585-8

PMID:24875629 - Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.

Ding L et al. G3 (Bethesda) 2014 May 28;4(8):1373-84

PMID:27304859 - Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.

Polakova S et al. PLoS Genet 2016 Jun;12(6):e1006102

PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238

PMID:23628481 - A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Yu Y et al. DNA Repair (Amst) 2013 Jun 01;12(6):433-43

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:31563844 - The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stability.

Sparks JL et al. DNA Repair (Amst) 2019 Nov;83:102720

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:32541066 - RecQ DNA Helicase Rqh1 Promotes Rad3 ATR Kinase Signaling in the DNA Replication Checkpoint Pathway of Fission Yeast.

Ahamad N et al. Mol Cell Biol 2020 Aug 14;40(17)