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protein coding gene - atd2 (SPAC922.07c) - aldehyde dehydrogenase

Gene summary

Standard name
atd2
Systematic ID
SPAC922.07c
Product
aldehyde dehydrogenase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9URW9
ORFeome ID
24/24A10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5486848..5488758 reverse strand

Annotation

Disease association

MONDO:0859571 - diaphragmatic hernia 4, with cardiovascular defects

References:

MONDO:0014050 - isolated microphthalmia 8

References:

GO biological process

GO:0006598 - polyamine catabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004029 - aldehyde dehydrogenase (NAD+) activity

References:

Multi-locus phenotype

FYPO:0005776 - normal growth on acetaldehyde

References:

Genotypes:

FYPO:0005775 - sensitive to acetaldehyde

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003938 - increased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0005777 - increased number of Rad52 foci during cellular response to acetaldehyde

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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Genotypes:

FYPO:0005776 - normal growth on acetaldehyde

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Genotypes:

FYPO:0007331 - normal growth on formaldehyde

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00171AldedhAldehyde_DH_domPFAM
cd07144ALDH_ALD2-YMR170CCDD
PS00687ALDEHYDE_DEHYDR_GLUAld_DH_CS_GLUPROSITE_PATTERNS
G3DSA:3.40.309.10:FF:000012FUNFAM
G3DSA:3.40.605.10:FF:000001FUNFAM
SSF53720ALDH-likeAld_DH/histidinol_DHSUPERFAMILY
G3DSA:3.40.309.10Aldehyde Dehydrogenase; Chain A, domain 2Ald_DH_CGENE3D
G3DSA:3.40.605.10Aldehyde Dehydrogenase; Chain A, domain 1Ald_DH_NGENE3D
PTHR437202-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASEPANTHER

Orthologs

References / Literature

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.
Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.
Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605