protein coding gene - hsp90 (SPAC926.04c) - Hsp90 chaperone

Gene summary

Standard name

hsp90

Systematic ID

SPAC926.04c

Product

Hsp90 chaperone

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

swo1, git10

UniProt ID

P41887

ORFeome ID

28/28A02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3888558..3891139 reverse strand

Annotation

Protein features

Orthologs

• HSP90AA1 (HGNC:5253) Homo sapiens
• HSP90AB1 (HGNC:5258) Homo sapiens
• hsp90 (SJAG_01664) Schizosaccharomyces japonicus
• HSC82 (YMR186W) Saccharomyces cerevisiae
• HSP82 (YPL240C) Saccharomyces cerevisiae

References / Literature

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:16098195 - Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90.

Turnbull EL et al. FEBS J 2005 Aug;272(16):4129-40

PMID:31615333 - Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.

Nakazawa N et al. Open Biol 2019 Oct 31;9(10):190125

PMID:32499408 - The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast.

Sun L et al. J Cell Sci 2020 Jul 07;133(13)

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.

Morozumi Y et al. iScience 2024 Jan 19;27(1):108777

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

PMID:23319050 - Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.

Wang CY et al. Mol Cell Biol 2013 Mar;33(6):1244-53

PMID:19581297 - Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.

Li J et al. J Biol Chem 2009 Aug 28;284(35):23852-9

PMID:39040524 - Arsenite treatment induces Hsp90 aggregatesdistinct from conventional stress granules in fission yeast.

Tomimoto N et al. Microb Cell 2024;11:242-253

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:18430926 - Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

Alaamery MA et al. Genetics 2008 Apr;178(4):1927-36

PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.

Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72

PMID:39358553 - Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.

Anver S et al. EMBO Rep 2024 Oct 02;

PMID:8227198 - Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe.

Byrne SM et al. J Cell Sci 1993 Aug;105 ( Pt 4)(0 4):1095-100

PMID:8001792 - Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).

Nocero M et al. Genetics 1994 Sep;138(1):39-45

PMID:15755919 - Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.

Mishra M et al. Eukaryot Cell 2005 Mar;4(3):567-76

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:21127511 - Understanding of the Hsp90 molecular chaperone reaches new heights.

Vaughan CK et al. Nat Struct Mol Biol 2010 Dec;17(12):1400-4

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:31219728 - Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe .

Cipakova I et al. Cell Cycle 2019 Jul;18(14):1532-1536

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:12062100 - Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Saitoh S et al. Cell 2002 May 31;109(5):563-73

PMID:16990277 - Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions.

Nicolas E et al. J Biol Chem 2006 Nov 24;281(47):35983-8

PMID:10581266 - The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts.

Muñoz MJ et al. Genetics 1999 Dec;153(4):1561-72

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:10102358 - Genetic interactions between Hsp90 and the Cdc2 mitotic machinery in the fission yeast Schizosaccharomyces pombe.

Muñoz MJ et al. Mol Gen Genet 1999 Mar;261(2):242-50

PMID:7498728 - sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase.

Jin M et al. Genetics 1995 Jun;140(2):457-67

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:8832414 - The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways.

Santo PD et al. J Cell Sci 1996 Jul;109 ( Pt 7)(0 7):1919-1925

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.

Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.

Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:27664222 - A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe.

He Y et al. Nucleic Acids Res 2017 Jan 09;45(1):106-114

PMID:8196617 - Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe.

Shiozaki K et al. Mol Cell Biol 1994 Jun;14(6):3742-51

PMID:23664927 - Biochemical characterization and cooperation with co-chaperones of heat shock protein 90 from Schizosaccharomyces pombe.

Ishida M et al. J Biosci Bioeng 2013 Oct;116(4):444-8

PMID:11298745 - Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.

Goes FS et al. Eur J Biochem 2001 Apr;268(8):2281-9

PMID:22543982 - Hsp90 interaction with Cdc2 and Plo1 kinases contributes to actomyosin ring condensation in fission yeast.

Santino A et al. Curr Genet 2012 Aug;58(4):191-203

PMID:22461145 - Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae.

Flom GA et al. Curr Genet 2012 Jun;58(3):149-63

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:20976105 - Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Anderson HE et al. PLoS One 2010 Oct 18;5(10):e13488

PMID:27935167 - CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.

Inoue H et al. Genes Cells 2017 Jan;22(1):59-70

PMID:29974204 - How does Hsp90 function in RNAi-dependent heterochromatin assembly?

Kato H et al. Curr Genet 2019 Feb;65(1):87-91

PMID:7813446 - A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

Aligue R et al. EMBO J 1994 Dec 15;13(24):6099-106

PMID:2157626 - Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe.

Hoffman CS et al. Genetics 1990 Apr;124(4):807-16

PMID:37120429 - Nucleotide exchange is sufficient for Hsp90 functions in vivo.

Reidy M et al. Nat Commun 2023 Apr 29;14(1):2489

PMID:36361590 - Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe .

Selicky T et al. Int J Mol Sci 2022 Oct 24;23(21)

PMID:36799444 - Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.

Hirano Y et al. J Biochem 2023 Jun 30;174(1):33-46

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:29866182 - RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5.

Okazaki K et al. Epigenetics Chromatin 2018 Jun 04;11(1):26

PMID:11791728 - Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast.

Ki SW et al. Biosci Biotechnol Biochem 2001 Nov;65(11):2528-34

PMID:1849107 - Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Hoffman CS et al. Genes Dev 1991 Apr;5(4):561-71

PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.

Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237

PMID:32075773 - Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress.

Cabrera M et al. Cell Rep 2020 Feb 18;30(7):2430-2443.e4

PMID:33946513 - The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.

Yukawa M et al. Int J Mol Sci 2021 Apr 30;22(9)

PMID:24146635 - Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.

Vjestica A et al. PLoS Genet 2013;9(10):e1003886