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protein coding gene - fas1 (SPAC926.09c) - fatty acid synthase beta subunit Fas1

Gene summary

Standard name
fas1
Systematic ID
SPAC926.09c
Product
fatty acid synthase beta subunit Fas1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UUG0
ORFeome ID
34/34C03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3900130..3907054 reverse strand

Annotation

GO biological process

GO:0006633 - fatty acid biosynthetic process

References:

GO:0042759 - long-chain fatty acid biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005835 - fatty acid synthase complex

References:

GO molecular function

GO:0019171 - (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

References:

GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity

References:

GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity

References:

GO:0004318 - enoyl-[acyl-carrier-protein] reductase (NADH) activity

References:

GO:0004312 - fatty acid synthase activity

References:

GO:0016297 - fatty acyl-[ACP] hydrolase activity

References:

GO:0004321 - fatty-acyl-CoA synthase activity

References:

Modification

MOD:00595 - monomannosylated residue

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0001513 - normal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0005645 - resistance to Cutin-1

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

References:

Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0005645 - resistance to Cutin-1

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Subunit composition

PBO:0034730 - heteromeric(12)

References:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF00698Acyl_transf_1Acyl_transferase_domPfam
PF01575MaoC_dehydratasMaoC-like_domPfam
PF08354Fas1-AflB-like_helFas1/AflB-like_centralPfam
PF13452FAS1_DH_regionFAS1-like_DH_regionPfam
PF16073SATSATPfam
PF17828FAS_NFAS1_NPfam
PF17951FAS_meanderFAS_meanderPfam
PF22235FAS1_thioest_insPfam
cd03447FAS_MaoCCDD
SM00827PKS_ATAcyl_transferase_domSMART
PR01483FASYNTHASEFatty_acid_synthasePRINTS
G3DSA:1.20.930.70:FF:000001CATH-FunFam
G3DSA:3.10.129.10:FF:000017CATH-FunFam
G3DSA:3.20.20.70:FF:000078CATH-FunFam
G3DSA:3.30.1120.100:FF:000001CATH-FunFam
G3DSA:3.30.70.3330:FF:000001CATH-FunFam
G3DSA:3.40.366.10:FF:000003CATH-FunFam
G3DSA:3.40.366.10:FF:000006CATH-FunFam
G3DSA:1.20.1050.120CATH-Gene3D
G3DSA:1.20.930.70CATH-Gene3D
G3DSA:3.10.129.10CATH-Gene3D
G3DSA:3.20.20.70Aldolase_TIMCATH-Gene3D
G3DSA:3.30.1120.100CATH-Gene3D
G3DSA:3.30.70.3330CATH-Gene3D
G3DSA:3.40.366.10Ac_transferase_dom_sfCATH-Gene3D
G3DSA:6.10.140.1400CATH-Gene3D
G3DSA:6.10.60.10CATH-Gene3D
G3DSA:6.20.240.10CATH-Gene3D
SSF51412SUPERFAMILY
SSF52151Acyl_Trfase/lysoPLipaseSUPERFAMILY
SSF54637HotDog_dom_sfSUPERFAMILY
PTHR10982Fungal_FASPANTHER
PIRSF005562FAS_yeast_betaFas1/AflB-likePIRSF

Orthologs

References / Literature

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:30796050 - Ssu72 phosphatase is a conserved telomere replication terminator.
Escandell JM et al. EMBO J 2019 Apr 01;38(7)
PMID:36799444 - Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.
Hirano Y et al. J Biochem 2023 Jun 30;174(1):33-46
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.
Zemlianski V et al. J Cell Sci 2024 May 23;
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:37851576 - The LARP1 homolog Slr1p controls the stability and expression of proto-5'TOP mRNAs in fission yeast.
Mansouri-Noori F et al. Cell Rep 2023 Oct 31;42(10):113226
GO_REF:0000051 - S. pombe keyword mapping
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:9693066 - Cloning of the fatty acid synthetase beta subunit from fission yeast, coexpression with the alpha subunit, and purification of the intact multifunctional enzyme complex.
Niwa H et al. Protein Expr Purif 1998 Aug;13(3):403-13
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83
PMID:26869222 - Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.
Takemoto A et al. J Cell Sci 2016 Mar 15;129(6):1250-9
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:39652606 - Cbf11 and Mga2 function together to activate transcription of lipid metabolism genes and promote mitotic fidelity in fission yeast.
Marešová A et al. PLoS Genet 2024 Dec 09;20(12):e1011509
PMID:15797383 - SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Hughes AL et al. Cell 2005 Mar 25;120(6):831-42