protein coding gene - utp7 (SPAC959.03c) - small subunit processome, U3 snoRNP-associated protein Utp7

Gene summary

Standard name: utp7
Systematic ID: SPAC959.03c
Product: small subunit processome, U3 snoRNP-associated protein Utp7
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9P4X3
ORFeome ID: 45/45B02
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 3389719..3391643 reverse strand

Annotation

GO biological process

GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

References:

GO_REF:0000033

GO cellular component

GO:0005730 - nucleolus

References:

PMID:16823372

GO:0032040 - small-subunit processome

References:

PMID:36423630

GO:0005732 - sno(s)RNA-containing ribonucleoprotein complex

References:

GO_REF:0000024

GO molecular function

GO:0030515 - snoRNA binding

References:

GO_REF:0000024

Modification

MOD:01149 - sumoylated lysine

References:

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Protein features

PBO:0111751 - WD repeat protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

PMID:33313903

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

utp7delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

utp7delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00400	WD40	WD40_rpt	Pfam
PF08149	BING4CT	BING4_C_dom	Pfam
PS00678	WD_REPEATS_1	WD40_repeat_CS	PROSITE patterns
PS50082	WD_REPEATS_2	WD40_rpt	PROSITE profiles
PS50294	WD_REPEATS_REGION		PROSITE profiles
SM00320	WD40	WD40_rpt	SMART
SM01033	BING4CT	BING4_C_dom	SMART
G3DSA:2.130.10.10:FF:000378			CATH-FunFam
G3DSA:2.130.10.10		WD40/YVTN_repeat-like_dom_sf	CATH-Gene3D
SSF50978		WD40_repeat_dom_sf	SUPERFAMILY
PTHR14085		WDR46/Utp7	PANTHER
Coil			COILS
mobidb-lite-Disorder	disorder_prediction		MobiDB-Disorder

Orthologs

WDR46 (HGNC:13923) Homo sapiens
utp7 (SJAG_04908) Schizosaccharomyces japonicus
UTP7 (YER082C) Saccharomyces cerevisiae

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.: Larochelle M et al. J Cell Sci 2019 May 31;132(11)
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.: Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.: Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.: Nie M et al. Sci Rep 2015 Sep 25;5:14389
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.: Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:36423630 - Chromatin localization of nucleophosmin organizes ribosome biogenesis.: Ugolini I et al. Mol Cell 2022 Dec 01;82(23):4443-4457.e9