protein coding gene - SPAC959.06c - alpha/beta hydrolase fold

Gene summary

Systematic ID: SPAC959.06c
Product: alpha/beta hydrolase fold
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: P0CS92
Characterisation status: conserved unknown
Feature type: mRNA gene
Genomic location: chromosome I: 3398024..3398701 reverse strand

Annotation

GO molecular function

GO:0003824 - catalytic activity

References:

GO_REF:0000050

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

PMID:11152613

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000011 - RNA level increased

References:

PMID:34460892

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000478 - normal meiosis

References:

PMID:16169489

Genotypes:

SPAC959.06cdelta/SPAC959.06cdelta

FYPO:0002060 - viable vegetative cell population

References:

PMID:23697806

Genotypes:

SPAC959.06cdelta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

SPAC959.06cdelta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Warnings

PBO:0000070 - gene structure updated

References:

PMID:21511999

PBO:0002035 - unmerged

References:

PMID:21511999

Protein features

ID	Name	InterPro name	DB name
SSF53474	alpha/beta-Hydrolases	AB_hydrolase_fold	SUPERFAMILY
G3DSA:3.40.50.1820	alpha/beta hydrolase	AB_hydrolase_fold	GENE3D
PTHR42103	ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN		PANTHER

Orthologs

SJAG_04664 Schizosaccharomyces japonicus

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.: Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.: Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.: Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.: Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model