protein coding gene - ayr2 (SPAC977.08) - 1-acyl DHAP reductase Ayr2

Gene summary

Standard name: ayr2
Systematic ID: SPAC977.08
Product: 1-acyl DHAP reductase Ayr2
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: P0CU00
ORFeome ID: 51/51B09
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 44704..45468 forward strand

Annotation

Disease association

MONDO:0009025 - apparent mineralocorticoid excess

References:

PB_REF:0000006

GO biological process

GO:0006654 - phosphatidic acid biosynthetic process

References:

GO_REF:0000024

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005783 - endoplasmic reticulum

References:

GO_REF:0000024

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0000140 - acylglycerone-phosphate reductase (NADP+) activity

References:

GO_REF:0000024

Genome organisation

PBO:0000066 - telomeric duplication

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000096 - sensitive to cadmium

References:

PMID:18684775

Genotypes:

ayr2delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

ayr2delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

ayr2delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF00106	adh_short	SDR_fam	PFAM
PR00081	GDHRDH	SDR_fam	PRINTS
PR00080	SDRFAMILY	SDR_fam	PRINTS
SSF51735	NAD(P)-binding Rossmann-fold domains	NAD(P)-bd_dom_sf	SUPERFAMILY
G3DSA:3.40.50.720			GENE3D
PTHR43976	SHORT CHAIN DEHYDROGENASE	SDR_oxidoreductase	PANTHER

Orthologs

BDH1 (HGNC:1027) Homo sapiens
HSD11B2 (HGNC:5209) Homo sapiens
HSD17B2 (HGNC:5211) Homo sapiens
AYR1 (YIL124W) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.: Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PANTHER:PTHR43490 - Unknown title
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623