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protein coding gene - plb4 (SPAC977.09c) - phospholipase Plb4

Gene summary

Standard name
plb4
Systematic ID
SPAC977.09c
Product
phospholipase Plb4
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P0CU02
ORFeome ID
51/51E06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 45875..48160 reverse strand

Annotation

Disease association

MONDO:0018794 - cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder

References:

GO biological process

GO:0046475 - glycerophospholipid catabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005783 - endoplasmic reticulum

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GO:0009897 - external side of plasma membrane

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GO:0005576 - extracellular region

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GO:0009277 - fungal-type cell wall

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GO:0005634 - nucleus

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GO molecular function

GO:0004623 - A2-type glycerophospholipase activity

References:

GO:0004622 - phosphatidylcholine lysophospholipase A1 activity

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Genome organisation

PBO:0000066 - telomeric duplication

Modification

MOD:00006 - N-glycosylated residue

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Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF01735PLA2_BLysoPLipase_cat_domPFAM
cd07203cPLA2_Fungal_PLBCDD
PS51210PLA2CLysoPLipase_cat_domPROSITE_PROFILES
SM00022pla2_6LysoPLipase_cat_domSMART
G3DSA:3.40.1090.10:FF:000010FUNFAM
SSF52151FabD/lysophospholipase-likeAcyl_Trfase/lysoPLipaseSUPERFAMILY
G3DSA:3.40.1090.10Cytosolic phospholipase A2 catalytic domainGENE3D
PTHR10728CYTOSOLIC PHOSPHOLIPASE A2PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7