protein coding gene - SPAC977.12 - L-asparaginase

Gene summary

Systematic ID: SPAC977.12
Product: L-asparaginase
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UTS7
ORFeome ID: 51/51C10
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 56492..57736 forward strand

Annotation

GO biological process

GO:0006530 - L-asparagine catabolic process

References:

GO_REF:0000033

GO:0019740 - nitrogen utilization

References:

GO_REF:0000111

GO cellular component

GO:0009986 - cell surface

References:

GO_REF:0000051

GO:0042597 - periplasmic space

References:

GO_REF:0000033

GO molecular function

GO:0004067 - asparaginase activity

References:

GO_REF:0000033

Modification

MOD:00006 - N-glycosylated residue

References:

PMID:36408920

Protein sequence feature

SO:0000418 - signal_peptide

References:

PMID:36408920

SO:0001812 - transmembrane_helix

References:

PMID:11152613

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

PMID:33313903

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:24763107

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0006680 - sensitive to bisphenol A

References:

PMID:30647105

Genotypes:

SPAC977.12delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

SPAC977.12delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

SPAC977.12delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF00710	Asparaginase	L-asparaginase_N	Pfam
PF17763	Asparaginase_C	Asparaginase_C	Pfam
cd08964	L-asparaginase_II	AsnASE_II	CDD
PS51732	ASN_GLN_ASE_3	Asparaginase/glutaminase-like	PROSITE profiles
SM00870	Asparaginase	Asparaginase/glutaminase-like	SMART
PR00139	ASNGLNASE	Asparaginase/glutaminase-like	PRINTS
G3DSA:3.40.50.1170:FF:000001			CATH-FunFam
G3DSA:3.40.50.1170		L-asparaginase_N_sf	CATH-Gene3D
G3DSA:3.40.50.40		L-asparaginase_C	CATH-Gene3D
SSF53774		Asp/glu_Ase-like_sf	SUPERFAMILY
PTHR11707		Asparaginase/glutaminase-like	PANTHER
PIRSF001220	L-ASNase_gatD	Asparaginase/glutaminase-like	PIRSF
PIRSF500176	L_ASNase		PIRSF
TIGR00520	asnASE_II	AsnASE_II	NCBIFAM

Orthologs

ASPG (HGNC:20123) Homo sapiens
ASP3-1 (YLR155C) Saccharomyces cerevisiae
ASP3-2 (YLR157C) Saccharomyces cerevisiae
ASP3-3 (YLR158C) Saccharomyces cerevisiae
ASP3-4 (YLR160C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.: Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.: Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.: Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.: Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101