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protein coding gene - SPAC977.12 - L-asparaginase

Gene summary

Systematic ID
SPAC977.12
Product
L-asparaginase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTS7
ORFeome ID
51/51C10
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 56492..57736 forward strand

Annotation

GO biological process

GO:0006530 - L-asparagine catabolic process

References:

GO cellular component

GO:0009986 - cell surface

References:

GO:0042597 - periplasmic space

References:

GO molecular function

GO:0004067 - asparaginase activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0006680 - sensitive to bisphenol A

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF17763Asparaginase_CAsparaginase_CPFAM
PF00710AsparaginaseL-asparaginase_NPFAM
cd08964L-asparaginase_IIAsnASE_IICDD
PS51732ASN_GLN_ASE_3Asparaginase/glutaminase-likePROSITE_PROFILES
SM00870Asparaginase_2Asparaginase/glutaminase-likeSMART
PR00139ASNGLNASEAsparaginase/glutaminase-likePRINTS
G3DSA:3.40.50.1170:FF:000001FUNFAM
SSF53774Glutaminase/AsparaginaseAsp/glu_Ase-like_sfSUPERFAMILY
G3DSA:3.40.50.1170L-asparaginase_N_sfGENE3D
G3DSA:3.40.50.40L-asparaginase_CGENE3D
PTHR11707L-ASPARAGINASEAsparaginase/glutaminase-likePANTHER
PIRSF001220L-ASNase_gatDAsparaginase/glutaminase-likePIRSF
PIRSF500176L_ASNasePIRSF
TIGR00520asnASE_IIAsnASE_IINCBIFAM

Orthologs

References / Literature

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.
Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000051 - S. pombe keyword mapping
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650