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protein coding gene - ypt2 (SPAC9E9.07c) - GTPase Ypt2

Gene summary

Standard name
ypt2
Systematic ID
SPAC9E9.07c
Product
GTPase Ypt2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P17609
ORFeome ID
31/31F06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4447723..4449534 reverse strand

Annotation

Complementation

PBO:0012569 - does not functionally complement S. cerevisiae YPT1

References:

PBO:0017776 - functionally complemented by canine rab8

References:

PBO:0012568 - functionally complements S. cerevisiae SEC4

References:

GO biological process

GO:0032120 - ascospore-type prospore membrane formation

References:

GO:0006887 - exocytosis

References:

GO:0006893 - Golgi to plasma membrane transport

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GO:0006906 - vesicle fusion

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005768 - endosome

References:

GO:1990819 - mating projection actin fusion focus

References:

GO:0035974 - meiotic spindle pole body

References:

GO:0005634 - nucleus

References:

GO:0005886 - plasma membrane

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GO:0005628 - prospore membrane

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GO molecular function

GO:0005525 - GTP binding

References:

GO:0003924 - GTPase activity

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Modification

MOD:00441 - geranylgeranylated residue

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MOD:00046 - O-phospho-L-serine

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MOD:01148 - ubiquitinylated lysine

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Protein features

PBO:0111858 - Ypt subfamily

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0004572 - decreased exocytosis during vegetative growth

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Genotypes:

FYPO:0000538 - decreased protein secretion during vegetative growth

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Genotypes:

FYPO:0005737 - delayed onset of prospore membrane formation

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Genotypes:

FYPO:0002086 - exocytic vesicles present in increased numbers

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Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003541 - normal protein localization to meiotic spindle pole body

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Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00071RasSmall_GTPasePFAM
cd01867Rab8_Rab10_Rab13_likeCDD
PS51421RASSmall_GTPasePROSITE_PROFILES
PS51419RABPROSITE_PROFILES
PS51420RHOPROSITE_PROFILES
SM00174rho_sub_3Small_GTPaseSMART
SM00175rab_sub_5SMART
SM00176ran_sub_2SMART
SM00173ras_sub_4SMART
PR00449RASTRNSFRMNGPRINTS
G3DSA:3.40.50.300:FF:000363FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR47980LD44762PSmall_GTPase_RabPANTHER
CoilCoilCOILS
TIGR00231small_GTPSmall_GTP-bdNCBIFAM

Orthologs

References / Literature

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20130084 - A guaninine nucleotide exchange factor is a component of the meiotic spindle pole body in Schizosaccharomyces pombe.
Yang HJ et al. Mol Biol Cell 2010 Apr 01;21(7):1272-81
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:40931936 - Oligomerization and exocyst coupling underlie Spa2-mediated focusing of polarized growth in fission yeast.
Ren L et al. J Cell Sci 2025 Sep 01;138(17)
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:2112089 - Structural and functional analysis of ypt2, an essential ras-related gene in the fission yeast Schizosaccharomyces pombe encoding a Sec4 protein homologue.
Haubruck H et al. EMBO J 1990 Jun;9(6):1957-62
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:41335110 - High-resolution mapping of the actin fusion focus reveals myosin V-dependent formin transport for aster formation.
Thomas V et al. J Cell Biol 2026 Feb 02;225(2)
PMID:8298192 - Function of the ypt2 gene in the exocytic pathway of Schizosaccharomyces pombe.
Craighead MW et al. Mol Biol Cell 1993 Oct;4(10):1069-76
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.
Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:16980382 - Genetic evidence for phospholipid-mediated regulation of the Rab GDP-dissociation inhibitor in fission yeast.
Ma Y et al. Genetics 2006 Nov;174(3):1259-71
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27630265 - The exocytic Rabs Ypt3 and Ypt2 regulate the early step of biogenesis of the spore plasma membrane in fission yeast.
Imada K et al. Mol Biol Cell 2016 Nov 01;27(21):3317-3328
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:21899677 - Cdc42 regulates multiple membrane traffic events in fission yeast.
Estravís M et al. Traffic 2011 Dec;12(12):1744-58