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protein coding gene - oxa101 (SPAC9G1.04) - mitochondrial inner membrane insertase Oxa101

Gene summary

Standard name
oxa101
Systematic ID
SPAC9G1.04
Product
mitochondrial inner membrane insertase Oxa101
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
oxa1, oxa1-1, oxa1sp1
UniProt ID
O14300
ORFeome ID
20/20C03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1975203..1976603 forward strand

Annotation

Complementation

PBO:0011440 - functionally complements S. cerevisiae OXA1

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GO biological process

GO:0032979 - protein insertion into mitochondrial inner membrane from matrix

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GO cellular component

GO:0005743 - mitochondrial inner membrane

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GO:0005739 - mitochondrion

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GO molecular function

GO:0032977 - membrane insertase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0000256 - mutator

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Genotypes:

FYPO:0001437 - normal growth on antimycin A

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Genotypes:

FYPO:0003731 - normal growth on galactose carbon source

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0002634 - resistance to cobalt

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000086 - sensitive to tacrolimus

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF0209660KD_IMPYidC/Oxa/ALB_CPFAM
cd200695TM_Oxa1-likeCDD
PTHR12428OXA1YidC/ALB3/OXA1/COX18PANTHER
TIGR03592yidC_oxa1_ctermYidC/Oxa/ALB_CNCBIFAM

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.
Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:16911509 - The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast.
Gaisne M et al. FEMS Yeast Res 2006 Sep;6(6):869-82
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.
Ma Y et al. PLoS One 2011;6(8):e23422
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:27664110 - Loss of Msp1p in Schizosaccharomyces pombe induces a ROS-dependent nuclear mutator phenotype that affects mitochondrial fission genes.
Delerue T et al. FEBS Lett 2016 Oct;590(20):3544-3558
PMID:10712694 - The respiratory gene OXA1 has two fission yeast orthologues which together encode a function essential for cellular viability.
Bonnefoy N et al. Mol Microbiol 2000 Mar;35(5):1135-45
PMID:11250894 - Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA.
Hell K et al. EMBO J 2001 Mar 15;20(6):1281-8
PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.
Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6