PomBase home

protein coding gene - mzt1 (SPAC9G1.15c) - mitotic spindle organizing protein Mzt1

Gene summary

Standard name
mzt1
Systematic ID
SPAC9G1.15c
Product
mitotic spindle organizing protein Mzt1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
tam4
UniProt ID
P0CF96
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1985350..1985608 reverse strand

Annotation

GO biological process

GO:0051415 - microtubule nucleation by interphase microtubule organizing center

References:

GO:0051417 - microtubule nucleation by spindle pole body

References:

GO:0090307 - mitotic spindle assembly

References:

GO cellular component

GO:0000923 - equatorial microtubule organizing center

References:

GO:0000931 - gamma-tubulin ring complex

References:

GO:0008275 - gamma-tubulin small complex

References:

GO:0061497 - inner plaque of mitotic spindle pole body

References:

GO:0031021 - interphase microtubule organizing center

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0005634 - nucleus

References:

GO:0005819 - spindle

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0140475 - spindle pole body anchor activity

References:

Multi-locus phenotype

FYPO:0000940 - decreased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000620 - abnormal cell cycle arrest in mitotic metaphase

References:

Genotypes:

FYPO:0000234 - abnormal cytoplasmic interphase microtubule nucleation

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0002823 - abolished protein localization to mitotic spindle pole body during interphase

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0002825 - decreased protein localization to mitotic spindle

References:

Genotypes:

FYPO:0002822 - decreased protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

References:

Genotypes:

FYPO:0002462 - inviable branched, elongated vegetative cell

References:

Genotypes:

FYPO:0002113 - inviable curved vegetative cell

References:

Genotypes:

FYPO:0002889 - inviable elongated vegetative cell with abnormal septum

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

References:

Genotypes:

FYPO:0000733 - long mitotic spindle

References:

Genotypes:

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0002818 - microtubule bundles present in decreased numbers

References:

Genotypes:

FYPO:0002688 - mitotic spindle collapse without elongation during prophase

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

FYPO:0002826 - normal gamma-tubulin complex assembly

References:

Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0003126 - post-anaphase array absent from cell

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002112 - viable curved vegetative cell

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
PF12554MOZART1MZT1Pfam
PTHR28520MZT1PANTHER

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.
Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477
PMID:24006493 - Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).
Dhani DK et al. Mol Biol Cell 2013 Nov;24(21):3337-49
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23885124 - Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly.
Masuda H et al. Mol Biol Cell 2013 Sep;24(18):2894-906
PMID:28619713 - Molecular model of fission yeast centrosome assembly determined by superresolution imaging.
Bestul AJ et al. J Cell Biol 2017 Aug 07;216(8):2409-2424
PMID:32610137 - Promiscuous Binding of Microprotein Mozart1 to γ-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation.
Huang TL et al. Cell Rep 2020 Jun 30;31(13):107836
PMID:20360068 - Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR et al. Science 2010 Apr 30;328(5978):593-9
PMID:27053664 - Synergistic role of fission yeast Alp16GCP6 and Mzt1MOZART1 in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly.
Masuda H et al. Mol Biol Cell 2016 Jun 01;27(11):1753-63