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protein coding gene - cta4 (SPACUNK4.07c) - P-type ATPase family V, transmembrane protein dislocase Cta4

Gene summary

Standard name
cta4
Systematic ID
SPACUNK4.07c
Product
P-type ATPase family V, transmembrane protein dislocase Cta4
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
sev4, SPAPYUK71.01, SPAC2E11.07c
UniProt ID
O14072
ORFeome ID
48/48E05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2897989..2901970 forward strand

Annotation

GO biological process

GO:0140569 - extraction of mislocalized protein from ER membrane

References:

GO:0006874 - intracellular calcium ion homeostasis

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GO cellular component

GO:0005783 - endoplasmic reticulum

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GO:0005789 - endoplasmic reticulum membrane

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GO molecular function

GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

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GO:0140567 - membrane protein dislocase activity

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GO:0015662 - P-type ion transporter activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0006706 - abolished calcium-transporting ATPase activity

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Genotypes:

FYPO:0006707 - decreased calcium ion transport from cytosol to endoplasmic reticulum

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0001198 - increased cellular calcium level

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Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

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Genotypes:

FYPO:0001758 - increased protein phosphatase activity

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Genotypes:

FYPO:0002714 - protein mislocalized to Golgi apparatus

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Genotypes:

FYPO:0005514 - protein mislocalized to vacuole

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0009036 - resistance to benzamidine

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0007921 - sensitive to benzamidine

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Genotypes:

FYPO:0000098 - sensitive to calcium

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Genotypes:

FYPO:0000843 - sensitive to dithiothreitol

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00122E1-E2_ATPaseATPase_P-type_domAPfam
PF13246Cation_ATPasePfam
PF231432TM_P5A-ATPase2TM_P5A-ATPasePfam
cd07543P-type_ATPase_cationP5A-type_ATPaseCDD
PS00154ATPASE_E1_E2ATPase_P-typ_P_sitePROSITE patterns
PS01229COF_2PROSITE patterns
PR00119CATATPASEPRINTS
G3DSA:3.40.1110.10:FF:000058CATH-FunFam
G3DSA:3.40.50.1000:FF:000056CATH-FunFam
G3DSA:2.70.150.10CATH-Gene3D
G3DSA:3.40.1110.10ATPase_P-typ_cyto_dom_NCATH-Gene3D
G3DSA:3.40.50.1000HAD_sfCATH-Gene3D
SSF56784HAD-like_sfSUPERFAMILY
SSF81653ATPase_P-typ_transduc_dom_A_sfSUPERFAMILY
SSF81660ATPase_P-typ_cyto_dom_NSUPERFAMILY
SSF81665ATPase_P-typ_TM_dom_sfSUPERFAMILY
PTHR45630P-type_TPase_VPANTHER
TIGR01494ATPase_P-typeP_typ_ATPaseNCBIFAM
TIGR01657P-ATPase-VP-type_TPase_VNCBIFAM
SFLDF00027p-type_atpaseP_typ_ATPase_HD_domSFLD
SFLDG00002C1.7:_P-type_atpase_likeSFLD
SFLDS00003Haloacid_DehalogenaseSFLD
Transmembrane alpha helixDeepTMHMM
CoilCOILS

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:22132152 - P(5A)-type ATPase Cta4p is essential for Ca2+ transport in the endoplasmic reticulum of Schizosaccharomyces pombe.
Lustoza AC et al. PLoS One 2011;6(11):e27843
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:31201205 - Coordinated Roles of the Putative Ceramide-Conjugation Protein, Cwh43, and a Mn 2+ -Transporting, P-Type ATPase, Pmr1, in Fission Yeast.
Nakazawa N et al. G3 (Bethesda) 2019 Aug 08;9(8):2667-2676
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.
Morozumi Y et al. iScience 2024 Jan 19;27(1):108777
PMID:12058018 - The endoplasmic reticulum cation P-type ATPase Cta4p is required for control of cell shape and microtubule dynamics.
Façanha AL et al. J Cell Biol 2002 Jun 10;157(6):1029-39
PMID:32848252 - Closed mitosis requires local disassembly of the nuclear envelope.
Dey G et al. Nature 2020 Sep;585(7823):119-123
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:16394583 - The cation-transporting P-type ATPase Cta4 is required for assembly of the forespore membrane in fission yeast.
Yoshida SH et al. Genes Genet Syst 2005 Oct;80(5):317-24